The role of oxidants and antioxidants in psoriasis

Yıldırım, Mehmet; İnalöz, H. Serhat; Baysal, Vahide; Delibas, Namik

doi:10.1046/j.1468-3083.2003.00641.x

Cited by 110 publications

(106 citation statements)

References 13 publications

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“…15 ROS also has an important role in the pathogenesis of inflammatory reactions, particularly in inflammatory skin diseases such as psoriasis, and the natural antioxidant catalase is known to regulate ROS, thereby exerting a crucial effect in this inflammatory disease. 16,17 It is interesting to note at this stage that vitamin D3, through its specific receptor, has been shown to suppress psoriatic lesions topically. A potentially very important activity of VDR agonists is their capacity to inhibit T-helper 1 cell responses.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis: crucial role of LXR-α RNomics

et al. 2009

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Liver X receptor-alpha (LXR-a), being a member of the nuclear receptor/transcription factor family, has been widely recognized to have a pleiotropic effect in the regulation of genes involved in innate immunity, inflammation and cholesterol homeostasis. Keeping in view the fact that psoriasis is a chronic, inflammatory and autoimmune disease with a high turnover of keratinocytes, this study was addressed to understand the functional RNomics of the LXR-a gene in cultured primary keratinocytes derived from skin biopsies of human psoriatic lesions, and from symptomless skin of psoriatic patients and clinically healthy subjects. The results of this study revealed for the first time that the LXR-a gene has an inherent capacity to regulate genes coding for inflammatory cytokines, cell cycle, immunomodulation and reactive oxygen species scavenging within human keratinocytes. Moreover, LXR-a gene knockdown within normal human keratinocytes simulated the genomic profile observed in psoriatic skin lesions. On the basis of our study, we propose that restoration of LXR-a expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.

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Section: Discussionmentioning

confidence: 99%

Psoriasis: crucial role of LXR-α RNomics

et al. 2009

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“…Various results have been obtained in earlier studies on SOD activity in psoriatic patients. Therond et al [122 ]found substantial SOD activity in the fibroblasts and erythrocytes of Ps patients, while another study showed lower SOD activity in the psoriatic group and suggested that SOD activity is lower in Ps because of an insufficiency in the antioxidant system [123]. Several other studies have also reported suppressed SOD activity in neutrophils [124,125].…”

Section: Cellular Antioxidantsmentioning

confidence: 99%

Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease

Khmaladze

Nandakumar

Holmdahl³

2015

Int Arch Allergy Immunol

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Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exposure to Saccharomyces cerevisiae mannan in certain mouse strains. The disease was found to be triggered by mannan-activated macrophages, leading to the activation of a pathogenic interleukin-17 pathway involving innate lymphocytes. Interestingly, the production of reactive oxygen species protected the mice from the triggering of this pathway and ameliorated Ps and PsA development.

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“…Süperoksit dismutaz süperoksit radikalini H 2 O 2 'ye çeviren reaksiyonu katalizleyerek süperok-sit anyonunun hidroksil radikali gibi daha toksik bir ürüne dönüşmesini engeller (24) . Yapılan çalışmalarda, genel olarak SOD aktivitesi düşük olarak bildirilmiş-tir (11,25) . Bu düşüklük antioksidan sistem yetersizliği-ne bağlanmıştır.…”

Section: Discussionunclassified

“…Toksik H 2 O 2 ise CAT enziminin katalizörlüğünde gerçekleşen reaksiyonla H 2 O ve O 2 'ye dönüşmektedir (28) . Katalaz bazı çalışmalarda, yüksek bazı çalışmalarda değişmemiş, bazı çalışmalarda ise düşük bulunmuştur (25,27,29) . Katalaz aktivitesi artışının Şekil 1.…”

Section: Discussionunclassified