The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations

Yamaguchi, Tetsutaro; Kawaguchi, Akira; Kim, Yong‐Il; Haga, Shugo; Katayama, Kunihiro; Ishida, Hajime; Park, Soo‐Byung; Maki, Koutaro; Kimura, Ryosuke

doi:10.4041/kjod.2014.44.2.96

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The SNP rs8079702, in proximity to potassium channel gene KCNJ2, exhibited decreased longitudinal QTc variance (Mints, Zipunnikov, Khurram, Calkins, & Nazarian, 2014). Besides, it has been shown that associated with the timing of first tooth eruption and the number of teeth at one year of age were genotyped in Japanese and Korean populations (Yamaguchi et al, 2014). The mutation at rs8079702 may affect the binding of KCNJ2 gene to CEBPB protein by the Bioinformatics prediction (http://pubs.broad insti tute.org/mamma ls/haplo reg/ haplo reg.php) (Ward & Kellis, 2012).…”

Section: Discussionmentioning

confidence: 99%

The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population

Liu

Zhang

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

Background Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. Methods A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression. Results In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50–0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19–0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20–4.42; p = 0.012). Conclusions Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF.

show abstract

Section: Discussionmentioning

confidence: 99%

The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population

Liu

Zhang

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

show abstract

“…Estudios recientes proporcionan evidencia de la asociación entre los genes EDA y XEDAR y el apiñamiento dental 34 . Diversos estudios han proporcionado evidencia de las asociaciones entre los factores genéticos y los rasgos dentales comunes, como el tamaño de los dientes 35,36 .…”

Section: Síndromes Asociados a La Agenesiaunclassified

Avances en La Genética De La Formación Dental: Una Revisión

2014

View full text Add to dashboard Cite

RESUMENEl desarrollo de las estructuras dentarias es el resultado de un complejo proceso de interacciones recíprocas y secuenciales entre células epiteliales y mesenquimáticas. La organogénesis dental está bajo un estricto control genético donde intervienen factores de crecimiento, de transcripción, moléculas de señalización y proteínas que determinan las posiciones, número y forma de los diferentes dientes. El objetivo de esta revisión fue describir los aspectos embriológicos y moleculares de la formación dental y las anomalías asociadas a un defecto en el patrón genético. Se realizó una búsqueda de literatura en PubMed, Dentistry & Oral Sciences Source, Science Direct y Scielo. Se concluye que continúan los avances en genética dental que han permitido entender cómo las alteraciones de diferentes genes, factores reguladores y proteínas son los responsables de diversas anomalías dentales. Los avances en la bioingeniería dental podrán resolver muchos de los interrogantes que hoy tenemos. [Verbel N, Alfaro OA, Torres EA. Avances en la genética de la formación dental: una revisión. Ustasalud. 2014; 13 (2) ADVANCES IN THE GENETICS OF DENTAL DEVELOPMENT: A REVIEW ABSTRACTThe development of dental structures is the result of a complex process of reciprocal and sequential interactions between epithelial and mesenchymal cells. Tooth organogenesis is under strict genetic control, where involved growth factors, transcription factors, signaling molecules and proteins that determine the positions, number and shape of the individual teeth. The objective of this review was to describe the embryological and molecular aspects of dental development and the anomalies associated with a defect in the gene pattern. A literature search was done in databases such as PubMed, Dentistry & Oral Sciences Source, Science Direct and Scielo. We concluded that dental genetics have a steady progress, which involves frequent updating and these advances have allowed to understand how changes in different genes, regulatory factors and proteins are responsible for various dental anomalies. The advances in dental bioengineering can solve many of the questions we have today.Keywords: Genetics, Odontogenesis, Bioengineering, Pathology.Recibido para publicación: 13 de octubre de 2014. Aprobado para publicación: 23 de noviembre de 2014. INTRODUCCIÓNEl desarrollo normal del individuo depende de dos grandes factores. Estos son la regulación genética, definida como la influencia del plan genético establecido en el DNA y en el contenido en los cromosomas y la regulación epigenética, que incluye la influencia de los factores externos que inciden en el desarrollo 1 . Ferraris y Muñoz afirman que las célu-las de la cresta neural emigran hacia el mesodermo de los arcos braquiales para dar origen a componentes esqueléticos, óseos y cartilaginosos que incluyen los componentes de los tejidos conectivos que formarán el complejo pulpodentinario y los tejidos de sostén del diente como el hueso, ligamento periodontal y cemento 2 .En el curso del desarrollo de los órg...

show abstract

Three-dimensional symmetry and parallelism of the skeletal and soft-tissue poria in patients with facial asymmetry

et al. 2014

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was to examine the symmetry and parallelism of the skeletal and soft-tissue poria by three-dimensional (3D) computed tomographic (CT) imaging.MethodsThe locations of the bilateral skeletal and soft-tissue poria in 29 patients with facial asymmetry (asymmetric group) and 29 patients without facial asymmetry (symmetric group) were measured in 3D reconstructed models of CT images by using a 3D coordinate system. The mean intergroup differences in the anteroposterior and vertical angular deviations of the poria and their anteroposterior and vertical parallelism were statistically analyzed.ResultsThe symmetric and asymmetric groups showed significant anteroposterior angular differences in both the skeletal and the soft-tissue poria (p = 0.007 and 0.037, respectively; Mann-Whitney U-test). No significant differences in the anteroposterior and vertical parallelism of the poria were noted (p ≤ 0.05; Wilcoxon signed-rank test).ConclusionsIn general, the skeletal poria are parallel to the soft-tissue poria. However, patients with facial asymmetry tend to have asymmetric poria.

show abstract

The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations

Cited by 3 publications

References 25 publications

The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population

The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population

Avances en La Genética De La Formación Dental: Una Revisión

Three-dimensional symmetry and parallelism of the skeletal and soft-tissue poria in patients with facial asymmetry

Contact Info

Product

Resources

About