2018
DOI: 10.1080/01443615.2018.1474186
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The role of random cervical biopsies in addition to colposcopy-directed biopsies in detection of CIN2+

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Cited by 5 publications
(5 citation statements)
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“…These observations have led to the practice of taking multiple targeted biopsies from colposcopic abnormal areas and taking random biopsies from normal looking areas to improve the detection rate of high-grade CIN. It has been shown that multiple quadrant lesion-directed biopsies during colposcopy increased detection of high-grade CIN ( 13 , 19 , 21 - 23 ) and our results are consistent with this observation. The incremental benefit of taking multiple quadrant biopsies in improving the diagnosis of high-grade CIN is clear in our study.…”
Section: Discussionsupporting
confidence: 92%
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“…These observations have led to the practice of taking multiple targeted biopsies from colposcopic abnormal areas and taking random biopsies from normal looking areas to improve the detection rate of high-grade CIN. It has been shown that multiple quadrant lesion-directed biopsies during colposcopy increased detection of high-grade CIN ( 13 , 19 , 21 - 23 ) and our results are consistent with this observation. The incremental benefit of taking multiple quadrant biopsies in improving the diagnosis of high-grade CIN is clear in our study.…”
Section: Discussionsupporting
confidence: 92%
“…A Japanese study concluded that two targeted biopsies should be taken, and random biopsies at normal appearing quadrants are recommended for low-grade cytology ( 22 ). A study in Thailand concluded that multiple biopsies increased the sensitivity of CIN2+ detection ( 23 ). In our study, in addition to the first targeted biopsy, a second one could significantly improve the cumulative sensitivity of lesion-targeted biopsy by nearly 25%.…”
Section: Discussionmentioning
confidence: 99%
“…In Poland, the experts led by Professor R. Jach created the project named Meijer protocols [7]. Increasing the number of taken targeted sections and performing a random biopsy of the transformation zone in the case of higher screening irregularities significantly lifts sensitivity from 84% to 100% [14].…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, an American RCT only found 54% sensitivity in diagnosing CIN3 4 . Several other studies have also reported low sensitivity, and authors have suggested that biopsies also be taken from colposcopically normal areas 5–13 . Many studies suffer from verification bias, as the outcome depends on the biopsies from the very lesions identified by colposcopy.…”
Section: Introductionmentioning
confidence: 99%
“… 4 Several other studies have also reported low sensitivity, and authors have suggested that biopsies also be taken from colposcopically normal areas. 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 Many studies suffer from verification bias, as the outcome depends on the biopsies from the very lesions identified by colposcopy. Moreover, histopathological analysis, the gold standard, has been found to have only moderate interobserver reproducibility.…”
Section: Introductionmentioning
confidence: 99%