The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

Мулерова, Т. А.; Цыганкова, Д. П.; Chigisova, A.N.; Ogarkov, M. Yu.

doi:10.17116/profmed20212402152

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Развитие АГ у коренных жителей Горной Шории происходит на фоне срыва метаболических и адаптационных механизмов, сложившихся веками на уровне генотипа популяции, в значительно изменившихся условиях существования этноса. В результате АГ протекает у шорцев злокачествен- [25,27].…”

Section: этнические особенности развития и лечения артериальной гипер...unclassified

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Artamonova,

Bazdyrev,

Makarov

2024

Kompleks. probl. serdečno-sosud. zabol.

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HighlightsWe have identified regional peculiarities of traditional and non-traditional cardiovascular risk factors.We have defined and characterized clinical and organizational characteristics of the specialized care, prevention, and treatment of diseases of the circulatory system in the Kemerovo region - Kuzbass.Moreover, we have described the principles of innovative organizational models for improving care for patients with diseases of the circulatory system, focused on the needs of outpatient organizations. AbstractThe review presents the main research findings obtained at the Department of Optimization of Medical Care for Cardiovascular Diseases of the Research Institute for Complex Issues of Cardiovascular Diseases over the past 13 years of work. The uniqueness of the obtained data lies in the fact that we have identified regional peculiarities of cardiovascular risk factors in residents of an industrial region (using the Kemerovo region data). Data on monitoring of health and risk factors served as the basis for the development of innovative organizational models for improving care for patients with diseases of the circulatory system from the stage of primary care to tertiary care using a systematic and integrated approach, and situational analysis. Management decisions within models are based on international quality standards that reaffirm that risk-based management, the role of personnel and the work environment are the integral to the improvement of performance and the achievement of the main goals of medical organization. Using the project approach, we have implemented management tools for internal quality control and safety of patients and personnel.

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Section: этнические особенности развития и лечения артериальной гипер...unclassified

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Artamonova,

Bazdyrev,

Makarov

2024

Kompleks. probl. serdečno-sosud. zabol.

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Role of angiotensinogen gene polymorphisms (AGT: с. 174C>T and AGT: с. 235T>С) in children with obesity and cardiometabolic disorders

Evdokimova,

Novikova,

Nakhimov

et al. 2024

Medicinskij sovet

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Introduction. Obesity is a multifactorial disease that arises through the joint actions of multiple genetic and environmental factors. Identification of genetic markers of obesity, including their polymorphisms, especially in children of early and preschool age is an important field of diagnosis and prevention of the disease.Aim. To study the prevalence of single-nucleotide polymorphisms of the gene (AGT: с.174C>T, p.T174M (rs4762) and AGT: с.235T>С, p.M235T (rs699)) in children with obesity.Materials and methods. A total of 180 children aged 5–17 years were examined in a clinical case-control study. The case group included 120 obese subjects, of whom 60 were aged 5–10 years old and 60 were aged 11–17 years old. The control group included 60 subjects with normal body weight, of whom 30 were aged 5–10 years old and 30 were aged 11–17 years old. The subjects underwent measurement of physical development, carbohydrate metabolism, and lipid status, as well as daily blood pressure monitoring, and molecular genetic testing, in particular, gene polymorphisms (AGT: p.174C>T, p.T174M (rs4762) and AGT: p.235T>C, p.M235T (rs699)). Odds ratios (OR) and their 95% confidence intervals (CI) were calculated to assess the impact of polymorphisms on the development of obesity and obesity-associated conditions. Results. No association was established between the AGT gene polymorphism: c.174C>T and obesity and dyslipidemia in children aged 5–17 years old. We found an association between the AGT gene polymorphism c.235T>C and obesity and dyslipidemia in children aged 5–17 years old (OR 3.1 [0.1; 3.9], p = 0.000001; OR 1.6 [0.9; 3.3], p = 0011). An association between both polymorphisms and the development of arterial hypertension (AH) in children and adolescents with obesity (OR 1.2 [0.4; 2.7], p = 0.000025; OR 2.2 [0.5; 2.4], p = 0.00002) was established.Discussion. Numerous works performed by foreign authors demonstrated the association between the AGT gene polymorphism: p.235T>C and the development of obesity and related comorbid conditions in adults. There is no information on the effect of the AGT polymorphism: p.174C>T.Conclusion. The renin-angiotensin-aldosterone system (RAAS) gene polymorphisms contribute to the development of obesity, dyslipidemia and hypertension in childhood.

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The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

Cited by 2 publications

References 15 publications

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Role of angiotensinogen gene polymorphisms (AGT: с. 174C>T and AGT: с. 235T>С) in children with obesity and cardiometabolic disorders

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