The role of sleep and wakefulness in myelin plasticity

Vivo, Luisa de; Bellesi, Michele

doi:10.1002/glia.23667

Cited by 50 publications

(45 citation statements)

References 114 publications

(162 reference statements)

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“…In both groups of RRMS patients no significant difference was found according to MoCA score, unlike the results of other studies reporting the influence of sleep quality on cognitive function [24,25]. Concurrent, all the RRMS patients with SD in the presence severe CI had poor performance in all cognitive domains with the lowest rate in memory and language.…”

Section: Discussioncontrasting

confidence: 75%

Sleep Disorders in Relapsing-Remitting Multiple Sclerosis Patients

Odintsova

Kopchak

2021

Wiad Lek

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The aim: Our study aimed at evaluating the relationships between sleep disorders (SD), cognitive impairment (CI), anxiety and depression in patients with relapsing-remitting multiple sclerosis (RRMS). Materials and methods: One hundred and five patients with RRMS (80 females and 25 males) aged from 22 to 67 years (mean age: 41,8±10,7; EDSS:3,5±1,6; disease duration (DD): 10,3±8,5 years) were enrolled into the study. All participants completed questionnaires on sleep (the Pittsburgh Sleep Quality Index /PSQI), cognitive functions (The Montreal Cognitive Assessment /MoCA), anxiety (Hamilton Anxiety Rating Scale /HAM-A), depression (Beck Depression Inventory/ BDI). Results: According to PSQI score the patients were divided into two groups: with (n=42) and without SD (n=63). The patients with SD were older (45,36±1,66 vs 39,41±1,27, p=0.005), had higher EDSS score (3,98±0,26 vs 3,14±0,19, p=0,008), BDI (13,79±1,14 vs 8,96±0,86, p=0,0009) and HAM-A (24,52±1,42 vs 16,56±0,99, p<0,0001) scales compared with patients without SD. The frequency of anxiety (p=0,0034) and depression (p=0,038) was significantly higher in RRMS patients with compared to those without SD. No significant difference was found in gender, DD and MoCA score. In patients with SD significant negative correlation between MoCA and BDI score (r = -0,42, p<0,005) was found. In the group of patients without SD significant negative correlation between MoCA and EDSS (r = -0,27, p=0,03), MoCA and BDI (r = -0,26, p=0,043),) MoCA and HAM-A (r = -0,25, p=0,041) score was detected. Conclusions: Insomnia type SD in RRMS patients were associated with older age, higher EDSS score and presence of anxiety and depression.

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Section: Discussioncontrasting

confidence: 75%

Sleep Disorders in Relapsing-Remitting Multiple Sclerosis Patients

Odintsova

Kopchak

2021

Wiad Lek

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“…Genes promoting OPC proliferation were mainly upregulated during sleep whereas OPC differentiation was mainly upregulated during awake. Such studies suggest that sleep is important for myelination ( de Vivo and Bellesi 2019 ). Myelin properties around the GM/WM boundary affect cortical thickness estimates ( Walhovd et al.…”

Section: Discussionmentioning

confidence: 99%

Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium

et al. 2020

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We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

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“…Acute or chronic sleep loss in rodent models also down-regulates several brain transcripts related to myelin function [ 6 , 11 , 12 ]. More specifically, our recent work has shown that ~5 days of sleep restriction in mice reduce myelin thickness and increase the length of Ranvier’s nodes in highly myelinated white matter tracts [ 7 , 10 ]. Such changes have a profound impact on reducing the velocity of the signal propagation along axons [ 13 ], which in turn may represent the neurophysiological basis of the cognitive and emotional problems resulting from sleep deprivation.…”

Section: Introductionmentioning

confidence: 99%

Sleep quality relates to emotional reactivity via intracortical myelination

Toschi

Passamonti

Bellesi

2020

Sleep

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A good quality and amount of sleep are fundamental to preserve cognition and affect. New evidence also indicates that poor sleep is detrimental for brain myelination. In this study, we test the hypothesis that sleep quality and/or quantity relate to variability in cognitive and emotional function via the mediating effect of inter-individuals differences in proxy neuroimaging measures of white-matter integrity and intra-cortical myelination. By employing a demographically and neuropsychologically well-characterized sample of healthy people drawn from the Human Connectome Project (n=974), we found that quality and amount of sleep were only marginally linked to cognitive performance. In contrast, poor quality and short sleep increased negative affect (i.e., anger, fear, and perceived stress) and reduced life satisfaction and positive emotionality. At the brain level, poorer sleep quality and shorter sleep duration related to lower intra-cortical myelin in the mid-posterior cingulate cortex (p=0.038), middle temporal cortex (p=0.024), and anterior orbitofrontal cortex (OFC, p=0.034) but did not significantly affect different measures of white-matter integrity. Finally, lower intra-cortical myelin in the OFC mediated the association between poor sleep quality and negative emotionality (p<0.05). We conclude that intra-cortical myelination is an important mediator of the negative consequences of poor sleep on affective behaviour.

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The role of sleep and wakefulness in myelin plasticity

Cited by 50 publications

References 114 publications

Sleep Disorders in Relapsing-Remitting Multiple Sclerosis Patients

Sleep Disorders in Relapsing-Remitting Multiple Sclerosis Patients

Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium

Sleep quality relates to emotional reactivity via intracortical myelination

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