The role of solute binding proteins in signal transduction

Matilla, Miguel A.; Ortega, Álvaro; Krell, Tino

doi:10.1016/j.csbj.2021.03.029

Cited by 44 publications

(59 citation statements)

References 210 publications

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“…In S. meliloti , the solute-binding protein ChoX binds acetylcholine ( 72 ). In Dickeya dadantii , acetylcholine was identified as a competitive antagonist that interacts with a ligand-gated ion channel ( 73 ). To the best of our knowledge, our data constitute the first report that bacteria sense acetylcholine as a strong chemoattractant via chemoreceptors.…”

Section: Discussionmentioning

confidence: 99%

Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine

Matilla

Velando

Tajuelo

et al. 2022

mBio

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Section: Discussionmentioning

confidence: 99%

Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine

Matilla

Velando

Tajuelo

et al. 2022

mBio

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“…However, microcalorimetric titrations of the individual PctA and PctC LBDs with histamine did not show binding [23]. It was thus suggested that histamine recognition by both receptors occurs via the binding of solute-binding proteins [23], an indirect mechanism for the activation of different bacterial sensor proteins that appears to be widespread among bacteria [63].…”

Section: Histamine and Hink Regulate P Aeruginosa Virulencementioning

confidence: 99%

Histamine: A Bacterial Signal Molecule

Krell

Gavira

Velando

et al. 2021

IJMS

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Bacteria have evolved sophisticated signaling mechanisms to coordinate interactions with organisms of other domains, such as plants, animals and human hosts. Several important signal molecules have been identified that are synthesized by members of different domains and that play important roles in inter-domain communication. In this article, we review recent data supporting that histamine is a signal molecule that may play an important role in inter-domain and inter-species communication. Histamine is a key signal molecule in humans, with multiple functions, such as being a neurotransmitter or modulator of immune responses. More recent studies have shown that bacteria have evolved different mechanisms to sense histamine or histamine metabolites. Histamine sensing in the human pathogen Pseudomonas aeruginosa was found to trigger chemoattraction to histamine and to regulate the expression of many virulence-related genes. Further studies have shown that many bacteria are able to synthesize and secrete histamine. The release of histamine by bacteria in the human gut was found to modulate the host immune responses and, at higher doses, to result in host pathologies. The elucidation of the role of histamine as an inter-domain signaling molecule is an emerging field of research and future investigation is required to assess its potential general nature.

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“…For example, P. aeruginosa PctA was identified to directly bind 17 amino acids and the autoinducer-2 (AI-2) [77,78]. In addition, PctA also mediates histamine chemotaxis using a mechanism that may involve indirect ligand recognition by solute binding protein [35,79].…”

Section: Rhizobacterial Mcps Sensing the Rhizosphere Chemoeffectorsmentioning

confidence: 99%

“…Structural and functional studies of dCache domains showed that ligands were almost exclusively bound to the membrane-distal module (Figure 1) [25,34,35,81,82], whereas there is only a single case for signal recognition at the membrane proximal module [83]. It was thus suggested that the primary roles of the membrane proximal module consists in the stimulus transmission to the transmembrane region [25] or the recognition of solute binding proteins [79]. A recent study demonstrated that the dCache domain containing McpB of Bacillus subtilis can directly bind ethanol at its cytoplasmic signaling domain, indicating the existance of alternative mechanisms for MCP stimulation [28].…”

Section: Rhizobacterial Mcps Sensing the Rhizosphere Chemoeffectorsmentioning

confidence: 99%

Chemotaxis of Beneficial Rhizobacteria to Root Exudates: The First Step towards Root–Microbe Rhizosphere Interactions

Feng

Hou

et al. 2021

IJMS

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Chemotaxis, the ability of motile bacteria to direct their movement in gradients of attractants and repellents, plays an important role during the rhizosphere colonization by rhizobacteria. The rhizosphere is a unique niche for plant–microbe interactions. Root exudates are highly complex mixtures of chemoeffectors composed of hundreds of different compounds. Chemotaxis towards root exudates initiates rhizobacteria recruitment and the establishment of bacteria–root interactions. Over the last years, important progress has been made in the identification of root exudate components that play key roles in the colonization process, as well as in the identification of the cognate chemoreceptors. In the first part of this review, we summarized the roles of representative chemoeffectors that induce chemotaxis in typical rhizobacteria and discussed the structure and function of rhizobacterial chemoreceptors. In the second part we reviewed findings on how rhizobacterial chemotaxis and other root–microbe interactions promote the establishment of beneficial rhizobacteria-plant interactions leading to plant growth promotion and protection of plant health. In the last part we identified the existing gaps in the knowledge and discussed future research efforts that are necessary to close them.

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The role of solute binding proteins in signal transduction

Abstract: Graphical abstract

Cited by 44 publications

References 210 publications

Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine

Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine

Histamine: A Bacterial Signal Molecule

Chemotaxis of Beneficial Rhizobacteria to Root Exudates: The First Step towards Root–Microbe Rhizosphere Interactions

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