The role of steroid hormones in ART

Loutradis, Dimitris; Beretsos, Panagiotis; Arabatzi, Eleni; Anagnostou, Evangelos; Drakakis, Peter

doi:10.1016/j.jsbmb.2008.09.010

Cited by 21 publications

(9 citation statements)

References 48 publications

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“…Our findings suggest a beneficial effect of high omega-3 intake on fertility outcome parameters because it has been shown that a mild ovarian stimulation regimen, resulting in fewer follicles, allows only the healthiest follicles and oocytes to develop into competent embryos (19). In addition, the existence of an E 2 window has been suggested (13,20). An increase above this threshold could affect uterine receptivity and be deleterious for embryonic implantation.…”

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confidence: 63%

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Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Hammiche

Vujkovic

Wijburg

et al. 2011

Fertility and Sterility

109

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confidence: 63%

“…The importance of baseline E 2 level for reproductive outcomes is controversial (13). Omega-3 is an essential source for cholesterol synthesis, which acts as a precursor of E 2 and other steroids.…”

mentioning

confidence: 99%

Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Hammiche

Vujkovic

Wijburg

et al. 2011

Fertility and Sterility

109

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“…In other studies by Sharara et al [4,7] and Papageorgiou et al [14] in which 106 and 905 IVF cycles were studied, respectively, no detrimental effect of high estradiol was seen on oocytes/ embryo quality or pregnancy rate. On the other hand, in the studies by Loutradis et al [13] and Pena et al [9,17], higher serum estradiol on the day of HCG was associated with a larger number of oocytes and embryos and highgrade embryos for transfer/cryopreservation. In our study, no correlation of serum estradiol with pregnancy rate was seen.…”

Section: Discussionmentioning

confidence: 83%

Serum Estradiol as a Predictor of Success of In Vitro Fertilization

Mittal

Gupta

Malhotra

et al. 2013

J Obstet Gynecol India

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Aim The aim of this study was to assess the role of total serum estradiol on the day of injection HCG, estradiol per mature follicle, and estradiol per oocytes retrieved (OR) on clinical pregnancy rate (CPR) and oocyte/embryo quality in assisted reproduction. Materials and Methods A retrospective review of 342 in vitro fertilization cycles with normal ovarian reserve in women who underwent long GnRH agonist protocol was included. The outcomes assessed are number of OR, number of mature oocytes (MO), number of oocytes fertilized (FO), fertilization rate, number of embryos cleaved (EC), cleavage rate (CR), number of Grade I embryos (E), number of cryopreserved embryos (CPE), and CPR. The Estradiol/follicle ratio (E2/fol) was defined as estradiol level per mature follicle [14 mm in diameter. Estradiol/ oocyte (E2/O) ratio was defined as estradiol level per OR. These two ratios were categorized by the 25th percentile into four groups. Results A positive correlation was seen between E2/fol and OR (r = .334, p value = .0001), MO (r = .335, p value = .0001), FO (r = .222, p value = .002), and CPE (r = .289, p value = .0001). Increased CPR was seen in Group C (E2/ fol = 200-299.99) compared to Group A, B, and D (p value = .033). With E2/O ratio, negative correlation was seen between E2/O and OR (r = -.281, p value = .002), MO (r = -.296, p value = .008), FO (r = -.220, p value = .003), EC (r = -.211, p value = .004), Grade 1 embryo (r = -.216, p value = .001), and CPE (r = -.206, p value = .005). No difference in FR, CR, or CPR was seen. No difference was seen in CPR with total serum estradiol. Conclusions In conclusion, serum estradiol is an important determinant of IVF success. While total serum estradiol does not exert any positive or negative influence on IVF outcome, estradiol per mature follicle and retrieved oocytes do have an impact. Pregnancy rate is better when E2/fol is between 200 and 299.99 pg/ml. Also, increasing serum E2/fol positively correlates with better oocytes and embryo quality. In contrast, E2/O negatively correlates with oocytes and embryo quality parameters.

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“…The use of progesterone supplementation has been an invaluable resource to Assisted Reproductive Technology (ART) efforts [60,61]. However, little is known about the action of progesterone during the implantation window in humans because the numerous molecular profiling efforts have been limited by the technologies available at the time or imprecise methods for endometrial cycle dating [62-66].…”

Section: Progesterone Receptormentioning

confidence: 99%

Role of nuclear receptors in blastocyst implantation

Vasquez

DeMayo

2013

Seminars in Cell & Developmental Biology

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The regulation of blastocyst implantation in the uterus is orchestrated by the ovarian hormones estrogen and progesterone. These hormones act via their nuclear receptors to direct the transcriptional activity of the endometrial compartments and create a defined period in which the uterus is permissive to embryo implantation termed the “window of receptivity”. Additional members of the nuclear receptor family have also been described to have a potential role in endometrial function. Much of what we know about the function of these nuclear receptors during implantation we have learned from the use of mouse models. Transgenic murine models with targeted gene ablation have allowed us to identify a complex network of paracrine signaling between the endometrial epithelium and stroma. While some of the critical molecules have been identified, the mechanism underlying the intricate communication between endometrial compartments during the implantation window has not been fully elucidated. Defining this mechanism will help identify markers of a receptive uterine environment, ultimately providing a useful tool to help improve the fertility outlook for reproductively challenged couples. The aim of this review is to outline our current understanding of how nuclear receptors and their effector molecules regulate blastocyst implantation in the endometrium.

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The role of steroid hormones in ART

Cited by 21 publications

References 48 publications

Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Serum Estradiol as a Predictor of Success of In Vitro Fertilization

Role of nuclear receptors in blastocyst implantation

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