The Role of the Mast Cell in Skin Aging

Yang-lin, Hua; Wei, Gao; Li, Hongying; Jian, Tang

doi:10.23937/2469-5750/1510035

Cited by 4 publications

(6 citation statements)

References 55 publications

(59 reference statements)

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“…MCs have been reported to be very important as regulators of epidermal barrier function and skin homeostasis and play important roles in wound healing and skin aging [ 6 , 22 , 23 , 24 , 25 , 26 , 27 ]. Their role in skin homeostasis has been often reported, but so far, the underlying mechanisms could not be identified in detail.…”

Section: Role Of Mast Cells In Barrier Integrity and Host Defensementioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

IJMS

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Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at the host–environment interfaces and equipped with a plethora of receptors, MCs also play an important role in the first-line defense against pathogens. Their main characteristic, the huge amount of preformed proinflammatory mediators embedded in secretory granules, allows for a rapid response and initiation of further immune effector cell recruitment. The same mechanism, however, may account for detrimental overshooting responses. MCs are not only detrimental in MC-driven diseases but also responsible for disease exacerbation in other inflammatory disorders. Focusing on the skin as the largest immune organ, we herein review both beneficial and detrimental functions of skin MCs, from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders. Moreover, we emphasize the importance of IgE-independent pathways of MC activation and their role in sustained chronic skin inflammation and disease exacerbation.

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Section: Role Of Mast Cells In Barrier Integrity and Host Defensementioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

IJMS

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“…Concerning intercellular regulation, keratinocytes and fibroblasts secrete prostaglandins which directly induce melanogenesis and an increase of dendricity 8 . These prostaglandins not only activate the melanocyte but also the mast cell, which in turn stimulates other cells such as macrophages, CD4 + T cells, basophils, dendritic cells, neutrophils, and inflammatory mediators such as histamine 9 . The result is the triggering of an inflammatory cascade which is evidenced by the infiltration of mast cells in biopsies of skin with melasma 10 …”

Section: Introductionmentioning

confidence: 99%

“…8 These prostaglandins not only activate the melanocyte but also the mast cell, which in turn stimulates other cells such as macrophages, CD4 + T cells, basophils, dendritic cells, neutrophils, and inflammatory mediators such as histamine. 9 The result is the triggering of an inflammatory cascade which is evidenced by the infiltration of mast cells in biopsies of skin with melasma. 10 Another key signalling pathway especially important in the pathophysiology of melasma is the vascular route.…”

mentioning

confidence: 99%

“…Activated mast cells secrete vascular endothelial growth factor (VEGF) which induces angiogenesis. 9 In fact, larger and elongated blood vessels and an increased expression of VEGF have been observed in skin with melasma, compared to perilesional skin. 11 The increase of blood vessels leads to a higher secretion of endothelial cells that secrete endothelin-1 (EDN1), which increases dendricity and stimulates melanogenesis.…”

mentioning

confidence: 99%

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Depigmenting topical therapy based on a synergistic combination of compounds targeting the key pathways involved in melasma pathophysiology

Martínez-Gutiérrez

Maribel

Pena-Rodríguez

et al. 2023

Experimental Dermatology

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Melasma has a complex pathophysiology with different cell types and signalling pathways involved. Paracrine factors secreted by keratinocytes, fibroblasts and endothelial cells act on melanocytes and stimulate melanogenesis. These paracrine factors are involved in the oxidative stress, inflammatory, vascular and hormonal pathways, among others. Damage of the dermoepidermal barrier also occurs and facilitates melanin deposition in the dermis, also known as dermal or mixed melasma. We used artificial intelligence tools to define the best combination of compounds for skin pigmentation inhibition. Mathematical models suggested the combination of retinol, diosmin and ferulic acid to be the most effective one. In vitro cellular tyrosinase activity assay proved that this combination had a synergistic depigmenting effect. Further assays proved that the combination could inhibit key pathways involved in melasma by downregulating ET‐1 and COX‐2 gene expression and IBMX‐induced dendricity in human melanocytes, and upregulated the gene expression of IL‐1b, TIMP3 and several endogenous antioxidant enzymes. The combination also reduced melanin levels in a phototype VI 3D epidermis model. These results indicate that the combination of retinol, diosmin and ferulic acid is an effective synergistic complex for the treatment of melasma by regulating the key molecular pathways involved in skin hyperpigmentation pathophysiology.

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“…Mast cells are immune cells that are a major factor in allergic and inflammatory responses [ 7 ]. Mast cells contain various allergens, cytokines, and chemokines that are released into the cells via the process of degranulation [ 8 ]. Mast cells are mainly present in the epidermis, immediately below the epidermis, or within the epidermis and are involved in inflammatory reactions in the skin [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice

et al. 2021

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Cone of Pinus densiflora (CP), or Korean red pinecone, is a cluster of Pinus densiflora fruit. CP has also been verified in several studies to have anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic effects. However, anti-inflammatory effects have not yet been confirmed in the inflammatory responses of pinecones to allergic contact dermatitis. The purpose of this study is to prove the anti-inflammatory effect of CP on allergic contact dermatitis (ACD) in vitro and in vivo. CP inhibited the expression of TSLP, TARC, MCP-1, TNF-α, and IL-6 in TNF-α/IFN-γ-stimulated HaCaT cells and MCP-1, GM-CSF, TNF-α, IL-6, and IL-8 in PMACI (phorbol-12-myristate-13-acetate plus A23187)-stimulated HMC-1 cells. CP inhibited the phosphorylation of mitogen-activated protein kinase (MAPKs), as well as the translocation of NF-κB on TNF-α/IFN-γ stimulated in HaCaT cells. In vivo, CP decreased major symptoms of ACD, levels of IL-6 in skin lesion, thickening of the epidermis and dermis, infiltration of eosinophils and mast cells, and the infiltration of CD4+ T cells and CD8+ T cells. This result suggests that CP represents a potential alternative medicine to ACD for diseases such as chronic skin inflammation.

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The Role of the Mast Cell in Skin Aging

Cited by 4 publications

References 55 publications

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Depigmenting topical therapy based on a synergistic combination of compounds targeting the key pathways involved in melasma pathophysiology

Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice

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