The Role of Transposable Elements in the Origin and Evolution of MicroRNAs in Human

Qin, Sheng; Park, Jin; Zhou, Xue; Chen, Liming; Ma, Fei

doi:10.1371/journal.pone.0131365

Cited by 69 publications

(66 citation statements)

References 35 publications

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“…In 2007, J. Piriyapongsa et al found that in humans TEs can be sources of microRNAs (Piriyapongsa et al, 2007), which was confirmed by other researchers (Yuan et al, 2010(Yuan et al, , 2011Qin et al, 2015). The key role of TEs in the formation of microRNAs and long ncRNAs (Johnson, Guigo, 2014;Kapusta, Feschotte, 2014) indicates that the maximum activity of TEs at the center of human neurogenesis (Kurnosov et al, 2015) as a natural phenomenon is necessary for epigenetic control of differentiation of neuronal stem cells.…”

Section: The Relationship Of Transposable Elements With Non-coding Rnmentioning

confidence: 83%

“…Despite the lack of mitotic activity of mature neurons, the specific expression of TEs in them is important in controlling both interneuronal interactions and the structural and functional characteristics of neurons (Bailie et al, 2011;Richardson et al, 2014;Erwin et al, 2016). These properties may be due to processing from transcripts of transposons of specific long ncRNAs (Lu et al, 2014;Honson, Macfarlan, 2018) and microRNAs (Piriyapongsa et al, 2007;Yuan et al, 2010Yuan et al, , 2011Qin et al, 2015). Indeed, in experiments on laboratory animals, the enrichment of specific miRNAs in certain structures and regions of neurons was revealed.…”

Section: The Role Of Retroelements In Interactions Between Neuronsmentioning

confidence: 99%

“…Transposable elements (TE) make up 69 % of the human genome (de Koning et al, 2011). In the course of evolution, many protein-coding genes (Joly-Lopez, Bureau, 2018), regulatory nucleotide sequences (Ito et al, 2017;Schrader, Schmitz, 2018), and telomeres (Kopera et al, 2011), non-coding RNAs (ncRNAs), including microRNAs (Piriyapongsa et al, 2007;Yuan et al, 2010Yuan et al, , 2011Qin et al, 2015) and long human ncRNAs (Johnson, Guigo, 2014) originating from TE. Over millions of years of evolution, cells have developed various defense systems against TE insertion into their genomes, including DNA methylation, heterochromatin formation, and RNA interference (RNAi).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of transposable elements in neurogenesis

Мустафин

Хуснутдинова

2020

Vestn. VOGiS

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The article is about the role of transposons in the regulation of functioning of neuronal stem cells and mature neurons of the human brain. Starting from the first division of the zygote, embryonic development is governed by regular activations of transposable elements, which are necessary for the sequential regulation of the expression of genes specific for each cell type. These processes include differentiation of neuronal stem cells, which requires the finest tuning of expression of neuron genes in various regions of the brain. Therefore, in the hippocampus, the center of human neurogenesis, the highest transposon activity has been identified, which causes somatic mosai cism of cells during the formation of specific brain structures. Similar data were obtained in studies on experimental animals. Mobile genetic elements are the most important sources of long non-coding RNAs that are coexpressed with important brain protein-coding genes. Significant activity of long non-coding RNA was detected in the hippocampus, which confirms the role of transposons in the regulation of brain function. MicroRNAs, many of which arise from transposon transcripts, also play an important role in regulating the differentiation of neuronal stem cells. Therefore, transposons, through their own processed transcripts, take an active part in the epigenetic regulation of differentiation of neurons. The global regulatory role of transposons in the human brain is due to the emergence of protein-coding genes in evolution by their exonization, duplication and domestication. These genes are involved in an epigenetic regulatory network with the participation of transposons, since they contain nucleotide sequences complementary to miRNA and long non-coding RNA formed from transposons. In the memory formation, the role of the exchange of virus-like mRNA with the help of the Arc protein of endogenous retroviruses HERV between neurons has been revealed. A possible mechanism for the implementation of this mechanism may be reverse transcription of mRNA and site-specific insertion into the genome with a regulatory effect on the genes involved in the memory.

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Section: The Relationship Of Transposable Elements With Non-coding Rnmentioning

confidence: 83%

Section: The Role Of Retroelements In Interactions Between Neuronsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Involvement of transposable elements in neurogenesis

Мустафин

Хуснутдинова

2020

Vestn. VOGiS

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“…1C). The palindromic nature of many transposons makes them plausible candidates for the evolutionary origin of miRNA genes (Piriyapongsa et al 2007;Roberts et al 2014;Qin et al 2015). For example, the placental-specific miR-1302 family was recently proposed to have originated from MER53 transposons (Yuan et al 2010).…”

Section: Discussionmentioning

confidence: 99%

DROSHA targets its own transcript to modulate alternative splicing

Lee

Nam

Shin

2017

RNA

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The nuclear RNase III enzyme DROSHA interacts with its cofactor DGCR8 to form the Microprocessor complex, which initiates microRNA (miRNA) maturation by cleaving hairpin structures embedded in primary transcripts. Apart from its central role in the biogenesis of miRNAs, DROSHA is also known to recognize and cleave miRNA-like hairpins in a subset of transcripts without apparent small RNA production. Here, we report that the human transcript is one such noncanonical target of DROSHA. Mammalian genes have evolved a conserved hairpin structure spanning a specific exon-intron junction, which serves as a substrate for the Microprocessor in human cells but not in murine cells. We show that it is this hairpin element that decides whether the overlapping exon is alternatively or constitutively spliced. We further demonstrate that DROSHA promotes skipping of the overlapping exon in human cells independently of its cleavage function. Our findings add to the expanding list of noncanonical DROSHA functions.

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“…В ряде случаев этот процесс опосредован LTR-содержащими ретроэлементами (или эндогенными ретровирусами -HERV) и LINE (long interspersed nuclear elements) [43]. Большинство транспозонов (ТЕ -transposable element) в геноме человека расположены в межгенных областях, являясь важными источниками микроРНК [47][48][49] и функциональных доменов днРНК [50]. Количество копий L1 в гиппокампе (центр нейрогенеза человека) оказалось больше по сравнению с другими органами одного и того же человека [51].…”

Section: перспективы исследования транспозоновunclassified

Genetics and epigenetics of attention deficit hyperactivity disorder

Мустафин¹,

Enikeeva²,

Malykh³

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Синдром дефицита внимания и гиперактивности (СДВГ)-сложное поведенческое расстройство [1] с высокой степенью наследуемости [2]. Оно характеризуется невнимательностью, гиперактивностью и импульсивностью [1]. Согласно DSM-5 cимптомы СДВГ возникают в возрасте до 12 лет, вызывая значительные нарушения социальных, академических и профессиональных функций на протяжении всей жизни [3]. Распространенность СДВГ

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The Role of Transposable Elements in the Origin and Evolution of MicroRNAs in Human

Cited by 69 publications

References 35 publications

Involvement of transposable elements in neurogenesis

Involvement of transposable elements in neurogenesis

DROSHA targets its own transcript to modulate alternative splicing

Genetics and epigenetics of attention deficit hyperactivity disorder

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