The role of type 2 diabetes mellitus on hypertensive‐related aortic stiffness

Sciatti, Edoardo; Vizzardi, Enrico; Assunta, Castiello; Valentini, Francesca; Bonadei, Ivano; Gelsomino, Sandro; Lorusso, Roberto; Metra, Marco

doi:10.1111/echo.13841

Cited by 11 publications

(12 citation statements)

References 46 publications

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“…Sciatti et al. 20 suggested that people suffering from T2DM and hypertension have more impaired aortic elastic properties than those with hypertensive alone. Non-enzymatic glycosylation of proteins in the arterial wall in the course of chronic hyperglycemia is associated with functional and structural changes within the aorta.…”

Section: Discussionmentioning

confidence: 99%

Local elasticity of the aorta in patients with type 2 diabetes mellitus

et al. 2020

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Objective Arterial elasticity is important for assessing the state of an artery. This cross-sectional study aimed to non-invasively examine stiffness parameters of the ascending aorta in patients with type 2 diabetes mellitus (T2DM). Methods We studied 58 patients, including 38 with T2DM and 20 controls. The stiffness of the aorta was evaluated during transthoracic echocardiography. Aortic parameters of stiffness, such as the stiffness index, elasticity index, and compliance index, were calculated using the aortic maximal diameter, aortic minimal diameter, and blood pressure. Results Pulse pressure values were significantly higher patients with T2DM than in controls. The β index was significantly higher in patients with T2DM lasting for >7 years compared with those with T2DM lasting for <7 years. Mean aortic compliance was significantly lower in patients with a longer duration of diabetes than in those with a shorter duration of diabetes. Aortic elasticity was significantly lower in patients with diabetes and arterial hypertension compared with patients without diabetes with concomitant arterial hypertension. Conclusions Patients with T2DM, especially when T2DM is long-term, have increased stiffness and decreased compliance of the ascending aorta. Pulse pressure, which is a cardiovascular risk factor, is also significantly increased in patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Local elasticity of the aorta in patients with type 2 diabetes mellitus

et al. 2020

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“…In the parasternal long-axis view, both systolic and diastolic inner diameters of the ascending aorta were measured via M-mode echocardiography 3 cm above the aortic annulus 11. Three measurements were obtained from 3 consecutive cardiac cycles and the mean values of aortic systolic diameter (AoSD) and aortic diastolic diameter (AoDD) were calculated 11. ASI was calculated by following formula:11,12…”

Section: Methodsmentioning

confidence: 99%

“…Three measurements were obtained from 3 consecutive cardiac cycles and the mean values of aortic systolic diameter (AoSD) and aortic diastolic diameter (AoDD) were calculated 11. ASI was calculated by following formula:11,12…”

Section: Methodsmentioning

confidence: 99%

“…An impaired aortic stiffness is a known cardiovascular risk factor and is related with other cardiovascular risk factors like age, hyperlipidemia, hypertension, diabetes, and smoking 8,9. Echocardiographic measurement of aortic stiffness index (ASI) is a simple and low-cost method that can provide satisfactory information about the aortic elasticity 10,11. ASI can be calculated by using the simple parameters such as blood pressure and systolic-diastolic aortic root diameters 12…”

Section: Introductionmentioning

confidence: 99%

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<p>Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus</p>

Turan

2019

DMSO

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PurposeMicroalbuminuria is a premature and widely used indicator of diabetic nephropathy and is reported to be related with a higher cardiovascular risk in diabetic patients. We aimed to examine whether the echocardiographic parameters, such as epicardial fat thickness (EFT), carotid intima-media thickness (CIMT) and aortic stiffness index (ASI) are associated with microalbuminuria in patients with diabetes mellitus type 2 (T2DM).Patients and methodsA total of 272 consecutive patients were enrolled and after the exclusion criteria, the data of 180 patients with T2DM were used in this cross-sectional study. Patients were divided into two groups: 82 patients with microalbuminuria and 98 patients without microalbuminuria (normoalbuminuria). The laboratory results and echocardiographic EFT, CIMT and ASI parameters were noted.ResultsCompared with the normoalbuminuria group, EFT, CIMT and ASI were significantly higher in the microalbuminuria group (p<0.05 for all). In logistic regression analysis; CIMT (OR: 3.15, p=0.024) and ASI (OR: 4.19, p=0.016) were independently associated with microalbuminuria in patients with T2DM.ConclusionIn addition to CIMT, as a novel finding, ASI which is an indicator for the elastic properties of the aortic root was independently associated with microalbuminuria. CIMT and ASI measurement by echocardiography may be helpful in identifying the accompanying factors in the development of nephropathy.

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“…Type 2 diabetes mellitus (T2DM), a glucose-, lipid-, proteinand water-electrolyte metabolic disorder, risks micro-and macrovascular damage (1). T2DM is associated with various chronic complications, which may result in high rates of disability and mortality (2).…”

Section: Introductionmentioning

confidence: 99%

Incremental effect of liraglutide on traditional insulin injections in rats with type 2 diabetes mellitus by maintaining glycolipid metabolism and cardiovascular function

Huang

Liu

et al. 2019

Exp Ther Med

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Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia, damaged insulin secretion and insulin resistance with high morbidity and mortality. Liraglutide (liragl) and insulin are effective hypoglycemic agents used in T2DM treatment. The potential effect of liragl in combination with insulin on T2DM remains unclear. The aim of the current study was to explore effects of liragl combined with insulin on glycolipid metabolism and cardiovascular function in rats with diabetes. A diabetes model was established in Sprague Dawley rats exposed to a high calorie and high sugar diet in conjunction with intraperitoneal injections of streptozotocin. Results indicated that liragl or insulin used alone decreased glucose and elevated insulin and c-peptide levels. However, their combination revealed greater effects. A significant increase in high-density lipoprotein cholesterol levels along with a decrease in total cholesterol, triglycerides and low-density lipoprotein cholesterol were observed in liragl-and insulin-treated rats compared with STZ-induced diabetes rats. Furthermore, co-administration of liragl and insulin significantly decreased sterol regulatory element-binding protein 1 levels and increased adenosine 5'-monophosphate kinase-α1 and carnitine palmitoyltransferase 1 expression. Combining liragl with insulin reduced myocardial hypertrophy level and gaps between cardiomyocytes compared with liragl or insulin treatment alone. Caspase-3 expression was significantly decreased by combination treatment of liragl and insulin. Oxidative damage was significantly decreased by co-administration of liragl and insulin through enhancing superoxide dismutase expression and reducing malondialdehyde. Furthermore, combination of liragl and insulin significantly reduced myocardial enzyme expression, including myoglobin, creatine kinase-muscle/brain and cardiac troponin I. In summary, the current study demonstrated synergistic effects of liragl and insulin injections on a T2DM rat model by maintaining glycolipid metabolism and cardiovascular function.

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The role of type 2 diabetes mellitus on hypertensive‐related aortic stiffness

Abstract: Our data suggest that people suffering from both T2DM and hypertension have more impaired aortic elastic properties than those hypertensive alone. Considering the prognostic role of aortic stiffness, these patients may benefit from a closer follow-up.

Cited by 11 publications

References 46 publications

Local elasticity of the aorta in patients with type 2 diabetes mellitus

Local elasticity of the aorta in patients with type 2 diabetes mellitus

<p>Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus</p>

Incremental effect of liraglutide on traditional insulin injections in rats with type 2 diabetes mellitus by maintaining glycolipid metabolism and cardiovascular function

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