2007
DOI: 10.1038/sj.bjc.6603766
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The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-β2

Abstract: Versican is a large chondroitin sulphate proteoglycan produced by several tumour cell types, including high-grade glioma. The increased expression of certain versican isoforms in the extracellular matrix (ECM) plays a role in tumour cell growth, adhesion and migration. Transforming growth factor-b2 (TGF-b2) is an important modulator of glioma invasion, partially by remodeling the ECM. However, it is unknown whether it interacts with versican during malignant progression of glioma cells. Here, we analysed the e… Show more

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Cited by 102 publications
(97 citation statements)
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“…A similar effect has been observed in smooth muscle cells, where versican silencing caused a diminished cell migration in wound healing assays (9), or in prostate cancer cells, in which addition of purified versican to the cells caused an increase in the invasion ability (13). In glioma, treatment of the cells with TGF-ß2 caused an increase in cell migration associated with an increase in versican production (10). CD44 inhibition also caused a reduction in the migration ability of melanoma cells, similarly to other cell types (27,40,41).…”
Section: Discussionsupporting
confidence: 49%
See 1 more Smart Citation
“…A similar effect has been observed in smooth muscle cells, where versican silencing caused a diminished cell migration in wound healing assays (9), or in prostate cancer cells, in which addition of purified versican to the cells caused an increase in the invasion ability (13). In glioma, treatment of the cells with TGF-ß2 caused an increase in cell migration associated with an increase in versican production (10). CD44 inhibition also caused a reduction in the migration ability of melanoma cells, similarly to other cell types (27,40,41).…”
Section: Discussionsupporting
confidence: 49%
“…In melanoma and other tumor cell types, versican has been shown to regulate cellular functions like cell proliferation, adhesion, migration and invasion (3,(7)(8)(9)(10). Versican is considered to be a pro-proliferative, anti-adhesive and promigratory molecule, and hence plays an important role in the development of tumors in many tissues (3,(11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%
“…54,55 Furthermore, TGF␤2-stimulated glioma cell migration was completely blocked by an antibody specific to the ADAMTS-cleaved neo-epitope of V0/V1 versican (amino acid sequence DPEAAE). 56 These findings from glioma progression underscore the important functional implications of proteoglycan processing by ADAMTS proteases in the progression to invasive metastatic cancer.…”
Section: Discussionmentioning
confidence: 84%
“…10 V0 and V1 are also the predominant isoforms found in cancer tissue. [11][12][13][14] Versican expression promotes tumor growth by destabilizing focal cell contacts, thus hampering cell adhesion and regulating angiogenesis. 10,15 Indeed, increased levels of versican have been reported in different tumor types such as adenocarcinomas, [16][17][18] squamous cell carcinomas, 19,20 sarcomas, 21 mesotheliomas 22 and malignant melanomas.…”
mentioning
confidence: 99%