The Role of Vitamins and Minerals in Psychiatry

Cornish, Stacey; Mehl‐Madrona, Lewis

doi:10.4137/117863370800300003

Cited by 24 publications

(10 citation statements)

References 68 publications

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“…Our data suggest that upregulation of TCN1 expression by hypomethylation in SZ patients reduces reality distortion symptoms, consistent with the observation of B12 deficiency-induced SZ-like symptoms. 54,55 Regarding medication influence, our test showed that hypermethylation of MS4A1 in patients was significantly influenced by medication dosage. Therefore, it was removed for genetic analyses.…”

Section: Discussionmentioning

confidence: 99%

Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients

Liu

Chen

Ehrlich

et al. 2013

Schizophrenia Bulletin

121

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DNA methylation, one of the main epigenetic mechanisms to regulate gene expression, appears to be involved in the development of schizophrenia (SZ). In this study, we investigated 7562 DNA methylation markers in blood from 98 SZ patients and 108 healthy controls. A linear regression model including age, gender, race, alcohol, nicotine and cannabis use status, and diagnosis was implemented to identify C-phosphate-G (CpG) sites significantly associated with diagnosis. These CpG sites were further validated using an independent data set. Sixteen CpG sites were identified with hyper-or hypomethylation in patients. A further verification of expression of the corresponding genes identified 7 genes whose expression levels were also significantly altered in patients. While such altered methylation patterns showed no correlation with disorganized symptoms and negative symptoms in patients, 11 CpG sites significantly correlated with reality distortion symptoms. The direction of the correlations indicates that methylation changes possibly play a protective mechanism to lessen delusion and hallucination symptoms in patients. Pathway analyses showed that the most significant biological function of the differentially methylated CpGs is inflammatory response with CD224, LAX1, TXK, PRF1, CD7, MPG, and MPO genes directly involved in activations of T cells, B cells, and natural killer cells or in cytotoxic reaction. Our results suggest that such methylation changes may modulate aspects of the immune response and hence protect against the neurobiological substrate of reality distortion symptoms in SZ patients.

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Section: Discussionmentioning

confidence: 99%

Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients

Liu

Chen

Ehrlich

et al. 2013

Schizophrenia Bulletin

121

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“…It commonly named as evening primrose, whose seeds include essential fatty acids (70% linoleic acid and 8–14% gamma linoleic acid) which their most important effect is healing of cyclic mastalgia [28, 29]. γ-linoleic acid is metabolized into homo γ-linoleic acid, subsequently inhibits arachidonic acid metabolites production which leads to anti-inflammatory effects [30].…”

Section: Resultsmentioning

confidence: 99%

Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review

et al. 2019

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“…Thiamine is used to treat patients with anxiety, and it was shown to improve many of the symptoms, suggesting an anxiolytic effect of thiamine [ 59 , 60 ]. Thiamine supplementation ameliorated the anxiety-like behavior of stressed-induced rats [ 47 ] and stress-induced mice [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

Wen

et al. 2020

Brain Sciences

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Thiamine deficiency (TD) has detrimental effects on brain health and neurobehavioral development, and it is associated with many aging-related neurological disorders. To facilitate TD-related neuropsychological studies, we generated a TD mouse model by feeding a thiamine-deficient diet for 30 days, followed by re-feeding the control diet for either one week or 16 weeks as recovery treatment. We then performed neurobehavioral tests in these two cohorts: cohort of one week post TD treatment (1 wk-PTDT) and 16 weeks post TD treatment (16 wks-PTDT). The TD mice showed no significant difference from control in any tests in the 1 wk-PTDT cohort at the age of 13–14 weeks. The tests for the 16 wks-PTDT cohort at the age of 28–29 weeks, however, demonstrated anxiety and reduced locomotion in TD animals in open field and elevated plus maze. In comparison, rotor rod and water maze revealed no differences between TD and control mice. The current findings of the differential effects of the same TD treatment on locomotion and anxiety at different ages may reflect the progressive and moderate change of TD-induced neurobehavioral effects. The study suggests that, even though the immediate neurobehavioral impact of TD is modest or negligible at a young age, the impact could develop and become severe during the aging process.

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The Role of Vitamins and Minerals in Psychiatry

Cited by 24 publications

References 68 publications

Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients

Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients

Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review

Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

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