The roles of long non‑coding RNAs in renal cell carcinoma (Review)

Abstract

Long non-coding RNAs (lncRNAs) are involved in the gene expression regulation and usually play important roles in various human cancers, including the renal cell carcinoma (RCC). Dysregulation of certain lncRNAs are associated with the prognosis of patients with RCC. In the present review, several recently studied lncRNAs were discussed and their critical roles in proliferation, migration, invasion, apoptosis and drug resistance of renal cancer cells were revealed. The research on lncRNAs further increases our understanding on the development and progression of RCC. It is suggested that lncRNAs can be used as biomarkers or therapeutic targets for diagnosis or treatment of renal cancer. Contents1. Introduction 2. Features and functions of lncRNAs in carcinogenesis 3. lncRNAs and RCC 4. Conclusions

Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies

“…ATB and FTX are also upregulated and their inhibition lead to a reduction in cell migration and invasion capacity. H19, TCL6, CAM1-AS1, GAS5 and LOC389332 act as tumor-suppressors, and are instead, downregulated; in particular, H19 and TCL6 are negatively correlated with TNM stage, lymph node metastases and distant metastases [ 116 ].…”