The ROS-generating enzyme NADPH oxidase 1 modulates the colonic microbiota but offers minor protection against dextran sulfate sodium-induced low-grade colon inflammation in mice

Herfindal, Anne Mari; Rocha, Sérgio Domingos Cardoso; Papoutsis, Dimitrios; Bøhn, Siv Kjølsrud; Carlsen, Harald

doi:10.1016/j.freeradbiomed.2022.06.234

Cited by 6 publications

(4 citation statements)

References 77 publications

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“… 18 The evidence shows that NOX modulates the colonic microbe in healthy and 1% dextran sulfate sodium (DSS)-induced low-grade inflammation mice model by producing ROS/RNS. 99 Transient enzymatic production of ROS by NOX1 and NOX2 within enterocytes occurs in response to specific taxa of intestinal bacteria. 15 Lactobacillus rhamnosus GG (LGG) has been not only been proven to increase NOX1 and activate the NRF2 pathway, but also to contribute to restoring the intestine microbiota, facilitating epithelial cell proliferation.…”

Section: Intestinal Microorganisms Act On Ferroptosismentioning

confidence: 99%

The influence of microbiota on ferroptosis in intestinal diseases

Yao,

2023

Gut Microbes

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Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant defenses. Multiple metabolic pathways, including iron and lipid metabolism, as well as antioxidant systems, contribute to the execution of ferroptosis. The gut microbiota exerts regulatory effects on ferroptosis through its microbial composition, biological functions, and metabolites. Notably, most pathogenic bacteria tend to promote ferroptosis, thereby inducing or exacerbating diseases, while most probiotics have been shown to protect against cell death. Given microbiota colonization in the gut, an intimate association is found between intestinal diseases and microbiota. This review consolidates the essential aspects of ferroptotic processes, emphasizing key molecules and delineating the intricate interplay between gut microbiota and ferroptosis. Moreover, this review underscores the potential utility of gut microbiota modulation in regulating ferroptosis for the treatment of intestinal diseases.

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Section: Intestinal Microorganisms Act On Ferroptosismentioning

confidence: 99%

The influence of microbiota on ferroptosis in intestinal diseases

Yao,

2023

Gut Microbes

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“…This is achieved through the production of luminal H 2 O 2 by the enzyme NADPH oxidase 1 (NOX1) in gut lining cells. NOX1-derived H 2 O 2 restricts microbial growth and preserves a buffer between the microbes and the colon surface [420,422].…”

Section: Time Cues That Facilitate Rhythmic Cooperationmentioning

confidence: 99%

Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping

Siebieszuk,

Sejbuk,

Witkowska

2023

IJMS

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The recently observed circadian oscillations of the intestinal microbiota underscore the profound nature of the human–microbiome relationship and its importance for health. Together with the discovery of circadian clocks in non-photosynthetic gut bacteria and circadian rhythms in anucleated cells, these findings have indicated the possibility that virtually all microorganisms may possess functional biological clocks. However, they have also raised many essential questions concerning the fundamentals of biological timekeeping, its evolution, and its origin. This narrative review provides a comprehensive overview of the recent literature in molecular chronobiology, aiming to bring together the latest evidence on the structure and mechanisms driving microbial biological clocks while pointing to potential applications of this knowledge in medicine. Moreover, it discusses the latest hypotheses regarding the evolution of timing mechanisms and describes the functions of peroxiredoxins in cells and their contribution to the cellular clockwork. The diversity of biological clocks among various human-associated microorganisms and the role of transcriptional and post-translational timekeeping mechanisms are also addressed. Finally, recent evidence on metabolic oscillators and host–microbiome communication is presented.

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“…La desregulación del equilibrio redox compromete la defensa antimicrobiana, y altera las respuestas inmunes innata y adaptativa. NADPH oxidasa es un importante productor de ERO las cuales están implicadas en el mantenimiento de una barrera epitelial saludable en el intestino y para la modulación de la microbiota (Herfindal et al, 2022). Aviello & Knaus, 2018, mencionan que las señales de NADPH/ERO están asociadas con activación de las células inmunes e inflamación en el tracto gastrointestinal.…”

Section: Discussionunclassified

“…Por otro lado, diversos estudios han demostrado que NADPH puede influir en la gravedad de la inflamación de bajo grado y en la composición bacteriana en el colon (Herfindal et al, 2022;Trevelin et al, 2020).…”

Section: Nadph Oxidasaunclassified

Relación del estrés oxidante con marcadores de inflamación en síndrome de intestino irritable

Morales Guzmán

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The ROS-generating enzyme NADPH oxidase 1 modulates the colonic microbiota but offers minor protection against dextran sulfate sodium-induced low-grade colon inflammation in mice

Cited by 6 publications

References 77 publications

The influence of microbiota on ferroptosis in intestinal diseases

The influence of microbiota on ferroptosis in intestinal diseases

Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping

Relación del estrés oxidante con marcadores de inflamación en síndrome de intestino irritable

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