The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®

Abstract

This review presents selected data on the probiotic strain Bifidobacterium animalis subsp. lactis BB-12® (BB-12®), which is the world’s most documented probiotic Bifidobacterium. It is described in more than 300 scientific publications out of which more than 130 are publications of human clinical studies. The complete genome sequence of BB-12® has been determined and published. BB-12® originates from Chr. Hansen’s collection of dairy cultures and has high stability in foods and as freeze dried powders. Strain characteristics and mechanisms of BB-12® have been established through extensive in vitro testing. BB-12® exhibits excellent gastric acid and bile tolerance; it contains bile salt hydrolase, and has strong mucus adherence properties, all valuable probiotic characteristics. Pathogen inhibition, barrier function enhancement, and immune interactions are mechanisms that all have been demonstrated for BB-12®. BB-12® has proven its beneficial health effect in numerous clinical studies within gastrointestinal health and immune function. Clinical studies have demonstrated survival of BB-12® through the gastrointestinal tract and BB-12® has been shown to support a healthy gastrointestinal microbiota. Furthermore, BB-12® has been shown to improve bowel function, to have a protective effect against diarrhea, and to reduce side effects of antibiotic treatment, such as antibiotic-associated diarrhea. In terms of immune function, clinical studies have shown that BB-12® increases the body’s resistance to common respiratory infections as well as reduces the incidence of acute respiratory tract infections.

Functional Gastrointestinal Disorders in Infants: Causes of Occurrance, Diagnostic Criteria and Possibilities of Correction With Probiotics

“…lactis ВВ-12 -один из самых изученных штаммов среди бифидобактерий [33]. B. lactis -компонент есте-ственной биопленки кишечника здоровых людей, содер-жится в грудном молоке и заселяет кишечник новорож-денного с первых часов жизни.…”

“…lactis (BВ-12) соответствует всем общепринятым критериям, предъявляемым к про-биотикам, в том числе фено-и генотипически охаракте-ризован (т. е. имеет «паспорт штамма») [33].…”

“…Благодаря клинической эффективности и безо-пасности штамм Bifidobacterium animalis subsp. lactis (ВВ-12) активно используют не только при производ-стве лекарственных препаратах, био-логически активных добавок к пище (БАД), но и в качестве ингредиента детских молочных смесей [33].…”

Susceptibility Pattern of Pseudomonas Aeruginosa Producing Enzymes Against Antimicrobial Agent Cell Free Supernatant of Lactococcus With the Focus on Its Determining Quantitatively by Od (Enzyme Linked Immune Sorbent Assay)

“…The effect of Lactococcus CFS was a variety from isolate to another because it is obscure of the production levels and properties among its compounds depend on the biochemical properties of the strain used and physical and chemical conditions of growth [5,26].…”

Antioxidant and Prebiotic Activity of Selected Edible Wild Plant Extracts

“…The beneficial bacteria types include the well-known probiotic strains B. animalis subsp. animalis, L. rhamnosus and L. acidophilus (Jungersen et al, 2014;Weese & Anderso, 2002). Alvarez-Olmos and Oberhelman (2001) and Tien et al (2006) described the mechanism of action for probiotics against gastrointestinal pathogens as based principally on: i) competition for nutrients and sites of adhession, ii) production of antimicrobial metabolites, iii) changing the gastrointestinal environmental conditions and, iv) modulation of the immune response of the host.…”