The Sclera and Its Role in Regulation of the Refractive State

Summers, Jody A.

doi:10.1007/978-1-4614-8338-0_5

Cited by 4 publications

(2 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The physical process of axial elongation appears to be dictated by the biomechanics of the sclera, which in turn are determined by the quantity/types of constituent components and their microstructural arrangement. 6 , 7 Presentation of myopigenic visual stimuli causes significant and rapid scleral remodeling, including changes in sulfated glycosaminoglycan (sGAG) levels and an increase in extensibility (i.e. altered biomechanics).…”

mentioning

confidence: 99%

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia

Brown

Kowalski

Paulus

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose The sclera is believed to biomechanically influence eye size, facilitating the excessive axial elongation that occurs during myopigenesis. Here, we test the hypothesis that the sclera will be remodeled and exhibit altered biomechanics in the mouse model of form-deprivation (FD) myopia, accompanied by altered retinoid concentrations, a potential signaling molecule involved in the process. Methods Male C57 Bl/6J mice were subjected to unilateral FD ( n = 44 eyes), leaving the contralateral eye untreated (contra; n = 44). Refractive error and ocular biometry were measured in vivo prior to and after 1 or 3 weeks of FD. Ex vivo measurements were made of scleral biomechanical properties (unconfined compression: n = 24), scleral sulfated glycosaminoglycan (sGAG) content (dimethylmethylene blue: n = 18, and immunohistochemistry: n = 22), and ocular all-trans retinoic acid (atRA) concentrations (retina and RPE + choroid + sclera, n = 24). Age-matched naïve controls were included for some outcomes ( n = 32 eyes). Results Significant myopia developed after 1 (−2.4 ± 1.1 diopters [D], P < 0.001) and 3 weeks of FD (−4.1 ± 0.7 D, P = 0.025; mean ± standard deviation). Scleral tensile stiffness and permeability were significantly altered during myopigenesis (stiffness = −31.4 ± 12.7%, P < 0.001, and permeability = 224.4 ± 205.5%, P < 0.001). Total scleral sGAG content was not measurably altered; however, immunohistochemistry indicated a sustained decrease in chondroitin-4-sulfate and a slower decline in dermatan sulfate. The atRA increased in the retinas of eyes form-deprived for 1 week. Conclusions We report that biomechanics and GAG content of the mouse sclera are altered during myopigenesis. All scleral outcomes generally follow the trends found in other species and support a retina-to-sclera signaling cascade underlying mouse myopigenesis.

show abstract

mentioning

confidence: 99%

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia

Brown

Kowalski

Paulus

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Ведущей причиной такого прогрессирующего и необратимого удлинения ПЗО признана нарастающая биомеханическая нестабильность склеральной оболочки миопического глаза, вызванная дистрофическими нарушениями ее соединительнотканного экстрацеллюлярного матрикса, в первую очередь снижением синтеза и увеличением деградации коллагена, а также снижением уровня его поперечной связанности (кросслинкинга) [34][35][36].…”

unclassified

Current assessment results of the efficacy and safety of scleroplasty in progressive myopia

Iomdina

Тарутта

Маркосян

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

The purpose of the review is to analyze the data of recent studies (performed in the last two decades) of the efficacy and safety of sclera reinforcement surgeries for progressive myopia in children and adults. Short-term and long-term observation results are presented, indicating the impact of the initial degree of myopia, the patient's age, surgical technique and the choice of plastic material on the outcome of the intervention and the further course of the myopic process. The advantages of a biologically active synthetic graft are described, which makes it possible to deposit drugs that stimulate scleral crosslinking and have a biomechanical, trophic and hemodynamic effect. Crosslinking of scleral collagen is a promising approach to the treatment of myopia.

show abstract

Intraocular pressure and myopia progression in Chinese children: the Anyang Childhood Eye Study

Iribarren

et al. 2018

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

The Sclera and Its Role in Regulation of the Refractive State

Cited by 4 publications

References 120 publications

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia

Current assessment results of the efficacy and safety of scleroplasty in progressive myopia

Intraocular pressure and myopia progression in Chinese children: the Anyang Childhood Eye Study

Contact Info

Product

Resources

About