The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated

Allmang, Christine; Wurth, Laurence; Krol, Alain

doi:10.1016/j.bbagen.2009.03.003

Cited by 164 publications

(119 citation statements)

References 86 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…1), into which dietary Se is ultimately shuttled (5). Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is co-translationally inserted during protein synthesis.…”

Section: Incorporation Of Dietary Se Into Selenoproteinsmentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

710

496

View full text Add to dashboard Cite

Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

show abstract

“…1), into which dietary Se is ultimately shuttled (5). Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is co-translationally inserted during protein synthesis.…”

Section: Incorporation Of Dietary Se Into Selenoproteinsmentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

710

496

View full text Add to dashboard Cite

show abstract

“…36,38,39 As reported in previous studies, the Luc-SECIS mechanism of selenoprotein synthesis and regulation remains elusive (reviewed in refs. [6][7][8][9][10]. While the function of most proteins is attributed to selenocysteine insertion, several (such as L30 and eIF4A3) are involved in other cellular processes, such as ribosome biogenesis, mRNA splicing and translation regulation (L30), or are part of the exon junction complex (eIF4A3).…”

Section: Introductionmentioning

confidence: 99%

“…Selenoprotein synthesis follows an unusual mechanism which involves the translational recoding of a UGA codon, normally used as a stop signal, into a selenocysteine insertion signal. [6][7][8][9][10] Cellular translation machinery uses UGA as a selenocysteine codon for selenoprotein mRNAs while selenocysteine insertion into selenoproteins involves the translational recoding of UGA stop codons. In mammals, selenoprotein expression further depends on selenium availability, which has been particularly described for glutathione peroxidase 1 and 4 (Gpx1 and Gpx4).…”

Section: Introductionmentioning

confidence: 99%

The differential expression of glutathione peroxidase 1 and 4 depends on the nature of the SECIS element

Latrèche¹,

Duhieu²,

Touat-Hamici³

et al. 2012

RNA Biology

View full text Add to dashboard Cite

“…Cristais S e T apresentaram melhores padrões de difração. Inserido na cadeia polipeptídica em resposta ao códon UGA, por uma complexa via de incorporação capaz de diferenciar o códon para Sec ou para terminação da síntese protéica 16,18 .…”

Section: Figura 1 3 -Sequências De Inserção Sec (Secis) Em A-secis unclassified

“…Em arqueobactérias e eucariotos sua localização na região 3'-UTR permite que juntamente com fatores trans, como a proteína SBP2, se associem ao EFSec 15,16 . Entretanto, também é sabido que nem todos os organismos existentes apresentam Selenoproteínas, como fungos e plantas superiores e que dessa forma as selenoproteínas não são essenciais para a vida por si só 7,17 .…”

Section: Figura 1 3 -Sequências De Inserção Sec (Secis) Em A-secis unclassified

Determinação estrutural da proteína Selenocisteína Sintase de Escherichia coli

Cassago¹

View full text Add to dashboard Cite

The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated

Cited by 164 publications

References 86 publications

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The differential expression of glutathione peroxidase 1 and 4 depends on the nature of the SECIS element

Determinação estrutural da proteína Selenocisteína Sintase de Escherichia coli

Contact Info

Product

Resources

About