The sentinel node in breast cancer

Collins, Conor D

doi:10.1102/1470-7330.2008.9003

Cited by 14 publications

(2 citation statements)

References 167 publications

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“…In general, radiopharmaceuticals outperform dyes, but when both are combined the potential of accurate staging is maximized. Combining dye, isotope and axillary node sampling further improves accuracy [7][8][9][10]. In addition, pre-operative lymphoscintigraphy aids the surgeon by determining the precise axillary location of the SLN [11].…”

Section: Jinst 7 P09010mentioning

confidence: 99%

Optimization of a gamma imaging probe for axillary sentinel lymph mapping

et al. 2012

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Sentinel lymph node (SLN) mapping is a technique for assessing whether early-stage invasive breast cancer has metastasized, thus determining prognosis and treatment options. SLN identification is achieved using the blue-dye and radioactive colloids techniques, which are sometimes combined with lymphoscintigraphy. Furthermore, intra-operative gamma acoustic probes, as well as gamma imaging probes are used during surgery. The purpose of this study is the construction of a gamma probe for sentinel lymph node imaging and its optimization in terms of sensitivity with respect to spatial resolution. The reference probe has small field of view (2.5×2.5 cm 2 ) and is based on a position sensitive photomultiplier tube (PSPMT) coupled to a pixellated CsI(Tl) scintillator. Following experimental validation, we simulated the system using the GATE Monte Carlo toolkit (GATE v6.1) and modeled various collimator geometries, in order to evaluate their performance and propose the optimal configuration. The constraints of the proposed gamma imaging probe are i) sensitivity close to 2 cps/kBq and ii) spatial resolution equal to 6 mm at 2 cm source-tocollimator distance and ∼10 mm at 5 cm. An integrated structure that achieves those requirements is a tungsten collimator with 2×2 mm 2 square holes, 16 mm thickness, 0.15 mm septa, where each CsI(Tl) 2×2×5 mm 3 crystal pixel is placed inside the collimator.

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Section: Jinst 7 P09010mentioning

confidence: 99%

Optimization of a gamma imaging probe for axillary sentinel lymph mapping

et al. 2012

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“…The most important prognostic factor is the axillary lymph node status [ 14–16 ] . The 10-year survival rate ranges from 30% (>10 nodes) to 70% (1–3 nodes) compared with 90% in those with no nodal disease.…”

Section: Stagingmentioning

confidence: 99%