The separate and combined effects of monoamine oxidase A inhibition and nicotine on resting state EEG

Smith, Dylan M.; Fisher, Derek J.; Blier, Pierre; Ilivitsky, Vadim; Knott, Verner

doi:10.1177/0269881115613518

Cited by 5 publications

(4 citation statements)

References 58 publications

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“…This improvement in performance suggests that with further training, animals with such lesions can overcome or suppress their perseverative habits, presumably, by developing alternate strategies supported by other PFC areas, such as the OFC. A recent study investigating the effects of neonatal lesions to the vlPFC and OFC separately or in combination demonstrated that, in the absence of a functional vlPFC in infancy, the OFC can take over and support learning skills (Malkova et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference

Weiss

Nadji

Bachevalier

2016

Front. Syst. Neurosci.

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The lateral prefrontal cortex is known for its contribution to working memory (WM) processes in both humans and animals. Yet, recent studies indicate that the prefrontal cortex is part of a broader network of interconnected brain areas involved in WM. Within the medial temporal lobe (MTL) structures, the perirhinal cortex, which has extensive direct interactions with the lateral and orbital prefrontal cortex, is required to form active/flexible representations of familiar objects. However, its participation in WM processes has not be fully explored. The goal of this study was to assess the effects of neonatal perirhinal lesions on maintenance and monitoring WM processes. As adults, animals with neonatal perirhinal lesions and their matched controls were tested in three object-based (non-spatial) WM tasks that tapped different WM processing domains, e.g., maintenance only (Session-unique Delayed-nonmatching-to Sample, SU-DNMS), and maintenance and monitoring (Object-Self-Order, OBJ-SO; Serial Order Memory Task, SOMT). Neonatal perirhinal lesions transiently impaired the acquisition of SU-DNMS at a short (5 s) delay, but not when re-tested with a longer delay (30 s). The same neonatal lesions severely impacted acquisition of OBJ-SO task, and the impairment was characterized by a sharp increase in perseverative errors. By contrast, neonatal perirhinal lesion spared the ability to monitor the temporal order of items in WM as measured by the SOMT. Contrary to the SU-DNMS and OBJ-SO, which re-use the same stimuli across trials and thus produce proactive interference, the SOMT uses novel objects on each trial and is devoid of interference. Therefore, the impairment of monkeys with neonatal perirhinal lesions on SU-DNMS and OBJ-SO tasks is likely to be caused by an inability to solve working memory tasks with high proactive interference. The sparing of performance on the SOMT demonstrates that neonatal perirhinal lesions do not alter working memory processes per se but rather impact processes modulating impulse control and/or behavioral flexibility.

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Section: Discussionmentioning

confidence: 99%

Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference

Weiss

Nadji

Bachevalier

2016

Front. Syst. Neurosci.

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“…It has been reported that while muscarinic blockers like scopolamine diminish the resting parieto-occipital alpha oscillations (Sannita et al, 1987 ; Sloan et al, 1992 ; Ebert et al, 1998 , 2001 ; Kikuchi et al, 1999 ; Osipova et al, 2003 ; Ramos Reis et al, 2013 ), nicotinic administration produces the reverse effect (Gilbert et al, 2000 ; Knott et al, 2000 , 2012 ; Walker et al, 2001 ; Bowers et al, 2015 ; Smith et al, 2016 ) but see (Knott and Fisher, 2007 ; Balsters et al, 2011 ; Fisher et al, 2012b ). Acetylcholine enhancers tend to increase posterior alpha power during visuospatial attentional modulations (Bauer et al, 2012 ) Figure 1c and frontal alpha during working memory tasks (Fisher et al, 2012a , 2013 ) but see (Eckart et al, 2016 ).…”

Section: Parieto-occipital Alpha Oscillations Are Modulated By a Myrimentioning

confidence: 99%

On the Physiological Modulation and Potential Mechanisms Underlying Parieto-Occipital Alpha Oscillations

Lozano-Soldevilla

2018

Front. Comput. Neurosci.

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The parieto-occipital alpha (8–13 Hz) rhythm is by far the strongest spectral fingerprint in the human brain. Almost 90 years later, its physiological origin is still far from clear. In this Research Topic I review human pharmacological studies using electroencephalography (EEG) and magnetoencephalography (MEG) that investigated the physiological mechanisms behind posterior alpha. Based on results from classical and recent experimental studies, I find a wide spectrum of drugs that modulate parieto-occipital alpha power. Alpha frequency is rarely affected, but this might be due to the range of drug dosages employed. Animal and human pharmacological findings suggest that both GABA enhancers and NMDA blockers systematically decrease posterior alpha power. Surprisingly, most of the theoretical frameworks do not seem to embrace these empirical findings and the debate on the functional role of alpha oscillations has been polarized between the inhibition vs. active poles hypotheses. Here, I speculate that the functional role of alpha might depend on physiological excitation as much as on physiological inhibition. This is supported by animal and human pharmacological work showing that GABAergic, glutamatergic, cholinergic, and serotonergic receptors in the thalamus and the cortex play a key role in the regulation of alpha power and frequency. This myriad of physiological modulations fit with the view that the alpha rhythm is a complex rhythm with multiple sources supported by both thalamo-cortical and cortico-cortical loops. Finally, I briefly discuss how future research combining experimental measurements derived from theoretical predictions based of biophysically realistic computational models will be crucial to the reconciliation of these disparate findings.

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“…Although ciproxifan is H3 receptor antagonist/inverse agonist, it also reversibly inhibits monoamine oxidase A and B at higher doses (Hagenow et al, 2017). Monoamine oxidase inhibitors are reported for the enhancement of theta modulation (McNaughton et al, 2007; Smith et al, 2016). Thus, the involvement of monoamine oxidase enzyme inhibition cannot be ruled out in the effects of ciproxifan.…”

Section: Discussionmentioning

confidence: 99%

Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders

et al. 2021

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Background: Central histamine H3 receptors are a family of presynaptic auto and heteroreceptors. Blockade of the presynaptic H3 receptors activates the downstream pathway(s) involved in the processes of learning and memory, making it a potential therapeutic option for ameliorating cognitive dysfunction. Samelisant (SUVN-G3031) is a potent and selective inverse agonist at the H3 receptors. Aim: The aim of this research is to study the effects of Samelisant in diverse animal models of cognitive functions. Methods: The effects of Samelisant on cognitive functions were studied using social recognition, object recognition and Morris water maze tasks. Neurochemical and electrophysiological effects of Samelisant were monitored using microdialysis and electroencephalography techniques. Results: Samelisant showed procognitive effects in diverse animal models of cognition at doses ranging from 0.3 to 3 mg/kg, per os ( p.o.) (social recognition and object recognition task). Samelisant significantly increased the brain acetylcholine levels in the cortex at doses of 10 and 20 mg/kg, p.o. In the Morris water maze task, combined administration of suboptimal doses of Samelisant and donepezil resulted in procognitive effects significantly larger than the either treatment. Similarly, Samelisant significantly potentiated the effects of donepezil on pharmacodynamic biomarkers of cognition i.e. acetylcholine levels in brain and neuronal theta oscillations. Conclusion: Samelisant may have potential utility in the treatment of cognitive deficits associated with hypocholinergic state.

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The separate and combined effects of monoamine oxidase A inhibition and nicotine on resting state EEG

Cited by 5 publications

References 58 publications

Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference

Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference

On the Physiological Modulation and Potential Mechanisms Underlying Parieto-Occipital Alpha Oscillations

Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders

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