The Series “Progress in the Chemistry of Organic Natural Products”: 75 Years of Service in the Development of Natural Product Chemistry

Soukup, Rudolf Werner; Soukup, Klara

doi:10.1007/978-3-319-05275-5_5

Cited by 3 publications

(1 citation statement)

References 143 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary metabolites are the heterogeneous group of naturally occurring compounds, which have been used to treat various diseases [46]. The biochemistry of medicines based on traditional natural products have made a tremendous contribution to public healthcare and has boosted the development of affordable medicines globally [47]. Secondary metabolites have been investigated extensively since the 1850s [48].…”

Section: Plant Secondary Metabolites: Key Target Playermentioning

confidence: 99%

A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery

et al. 2019

View full text Add to dashboard Cite

The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have resulted in the emergence of antimicrobial resistance. This has resulted in an increased interest in medicinal plants since 30–50% of current pharmaceuticals and nutraceuticals are plant-derived. The question we address in this review is whether plants, which produce a rich diversity of secondary metabolites, may provide novel antibiotics to tackle MDR microbes and novel chemosensitizers to reclaim currently used antibiotics that have been rendered ineffective by the MDR microbes. Plants synthesize secondary metabolites and phytochemicals and have great potential to act as therapeutics. The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.

show abstract

Section: Plant Secondary Metabolites: Key Target Playermentioning

confidence: 99%