The serotonergic system in fish

Lillesaar, Christina

doi:10.1016/j.jchemneu.2011.05.009

Cited by 267 publications

(277 citation statements)

References 218 publications

(431 reference statements)

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“…While these effects were found at rather high concentrations, more than 1 mg l 21 , studies have also found that fathead minnow [35] and hybrid striped bass [51] experienced reduced feeding rates after exposure to 3.7 and 250 mg l 21 of fluoxetine and venlafaxine, respectively. Lastly, serotonin plays an important role in modulating motor output and may either increase or decrease locomotion [64]. In a short-term exposure experiment, Arabian killifish showed reduced activity when exposed to low mg l 21 levels of fluoxetine [42], and a similar effect was observed for Siamese fighting fish [43][44][45] (table 2).…”

Section: (B) Pharmaceutical Effects On Fish Behaviour (I) Antidepressmentioning

confidence: 86%

“…Serotonin levels influence both physiology [60] and behaviour in a wide range of organisms, including fish [61,62], and play a pivotal role in activity, aggression and reproductive behaviours [62][63][64], which has been shown, for example, by a negative correlation between serotonin levels and levels of aggression [65,66]. It is therefore intuitive to use behavioural endpoints when studying effects of SSRIs and SNRIs, and several studies have evaluated impacts on various behaviours in fish (table 2).…”

Section: (B) Pharmaceutical Effects On Fish Behaviour (I) Antidepressmentioning

confidence: 99%

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Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Brodin

Piovano

Fick

et al. 2014

Phil. Trans. R. Soc. B

409

257

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The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields is currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations in fish, discuss potential ecological consequences and report results from an experiment in which we quantify both uptake and behavioural impact of a psychiatric drug on a predatory fish ( Perca fluviatilis ) and its invertebrate prey ( Coenagrion hastulatum ). We show that perch became more active while damselfly behaviour was unaffected, illustrating that behavioural effects of pharmaceuticals can differ between species. Furthermore, we demonstrate that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator. This suggests that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure. Wildlife may therefore be exposed to higher levels of behaviourally altering pharmaceuticals than predictions based on commonly used exposure assays and pharmaceutical concentrations found in environmental monitoring programmes.

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Section: (B) Pharmaceutical Effects On Fish Behaviour (I) Antidepressmentioning

confidence: 86%

Section: (B) Pharmaceutical Effects On Fish Behaviour (I) Antidepressmentioning

confidence: 99%

Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Brodin

Piovano

Fick

et al. 2014

Phil. Trans. R. Soc. B

409

257

View full text Add to dashboard Cite

show abstract

“…The brain was included as a positive control as several 5-HT signaling centers are located in this tissue [17]. Obtaining a detectable signal in brain tissue encouraged further study of the intestine.…”

Section: Discussionmentioning

confidence: 99%

“…), and 5-HT signaling was reported to decrease in mucosal biopsies from human patients with UC whereas colitis-models in rodents have reported an increase [16]. In zebrafish, 5-HT signalling has been detected in a number of tissues, for example the brain and CNS as well as in the intestine [17] [18]. The 5-HT involvement in neutrophil invasion and extracellular traps (NETS) in inflammatory tissues [19] suggest that 5-HT signalling may be worth investigating in the zebrafish-colitis model.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Chemically-Induced Colitis-Models in Adult Zebrafish, Using Optical Projection Tomography and Novel Transcriptional Markers

Haarder¹,

Kania²,

Holm³

et al. 2016

OJI

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Crohn's disease and ulcerative colitis-inflammatory bowel diseases (IBD)-are chronic conditions with an inadequately understood pathogenesis. Employing a set of novel molecular markers in a gene expression assay (qPCR), we have used adult zebrafish to investigate two acute inflammatory models, induced by the haptenizing agents oxazolone and TNBS. In addition, goblet cell dynamics in the scales and intestine and 5-HT (serotonin) in intestinal tissues were investigated through optical projection tomography. Gene expression studies revealed a distinct and significant upregulation of proinflammatory cytokines, acute-phase reactants and metalloprotease 9 in both chemical models, primarily after 72 hours. In comparison, transcription factors and cytokines associated with Th1 and Th17 (Crohn's) and Th2 (ulcerative colitis) were mainly not affected in this acute setting. However, elevated transcript levels were detected in Foxp3, IL-10 and T-bet, which are linked with tolerance and Tregs in mammals. Goblet cells in scales were depleted in both chemical models and in the intestine of oxazolone-treated fish. A marked 5-HT signal was noted in intestinal tissue of some chemically treated zebrafish. In conclusion, a distinct acute inflammatory reaction was induced in both chemical models. Further, oxazolone and TNBS did not result in clear-cut Th2 and Th1/Th17 pathway signaling at this early timepoint, but the applied molecular tools may provide further insight to the IBD pathogenesis and translational value of the IBD zebrafish model. How to cite this paper:

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“…Indeed, monoaminergic systems are globally well conserved and seem to serve the same types of functions in fish and mammals, with some anatomical and genetic exceptions 31,32 . These include the presence of 5-HT and DA cell bodies in the fish forebrain (5-HT 17,[33][34][35][36][37] ; DA 32,[38][39][40][41][42] ). Also, there are two tyrosine hydroxylases (THs) 43 , two tryptophan hydroxylases (TPH) 44 , and two putative COMT genes 32 in zebrafish (see Fig.…”

mentioning

confidence: 99%

A mutation in the enzyme monoamine oxidase explains part of the Astyanax cavefish behavioural syndrome

et al. 2014

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We use Astyanax mexicanus, a single species with surface-dwelling forms (SF) and blind de-pigmented cave forms (CF), to study mechanisms underlying the evolution of brain and behaviour. In CF, the origin of changes in complex motivated behaviours (social, feeding, sleeping, exploratory) is unknown. Here we find a hyper-aminergic phenotype in CF brains, including high levels and neurotransmission indexes for serotonin, dopamine and noradrenaline, and low monoamine oxidase (MAO) activity. Although MAO expression is unchanged in CF, a pro106leu mutation is identified in the MAO coding sequence. This mutation is responsible for low MAO activity and high serotonin neurotransmission index in CF brains. We find the same mutated allele in several natural CF populations, some being independently evolved. Such occurrence of the same allele in several caves may suggest that low MAO activity is advantageous for cave life. These results provide a genetic basis for several aspects of the cavefish 'behavioural syndrome'.

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The serotonergic system in fish

Cited by 267 publications

References 218 publications

Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Comparison of Two Chemically-Induced Colitis-Models in Adult Zebrafish, Using Optical Projection Tomography and Novel Transcriptional Markers

A mutation in the enzyme monoamine oxidase explains part of the Astyanax cavefish behavioural syndrome

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