The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Tóthová, Csilla; Nagy, Oskar; Kováč, G.

doi:10.2298/avb1306473t

Cited by 11 publications

(10 citation statements)

References 13 publications

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“…The authors did not fi nd blood lactate concentration to be useful in identifying early BRD, possibly because generalized body-tissue anaerobic metabolism did not have a chance to develop due to the low percentage of pulmonary involvement. Our results indicate higher lactate levels in calves with severe signs of respiratory disease, but these are frequently within the normal range [34][35][36]. Values over 1.5 mmol/l are considered risky regarding the prognosis and high proportion of animals, which die later on or must be culled from the herd.…”

Section: Discussionmentioning

confidence: 67%

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

et al. 2015

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The purpose of this study was to evaluate in calves the effects of respiratory diseases of various severities on blood gases, acid-base balance and plasma lactate concentration. We included in the study 128 calves with clinical signs of various severities and outcomes of respiratory disorders. The age of the calves ranged from 1 to 12 months. According to the clinical fi ndings, course of the disease and time of blood collection, the sick calves were divided into three groups: RD 1 (n=34) -calves with moderate clinical signs; RD 2 (n=73) -calves with severe respiratory symptoms and RD 3 (n=21) -calves with severe respiratory symptoms and died within 48 hours after blood sampling. Into the study we also included one group of 28 clinically healthy calves. In the arterial blood we evaluated: blood pH, partial pressure of carbon dioxide -pCO 2 , partial pressure of oxygen -pO 2 , concentration of actual bicarbonate -HCO 3 -, base excess -BE, and saturation of hemoglobin by oxygen -O 2 -sat. The concentration of lactate was determined in the blood plasma. Signifi cant effects of health status and severity of respiratory diseases were recorded in all the evaluated variables. Marked hypoxemia and hypercapnia were found in calves with severe respiratory disorders and in animals that died within 48 hours after blood collection. In most calves, the acid-base changes were characterized as compensated respiratory acidosis. The highest mean lactate values were recorded in calves that died within 48 hours after blood sampling. The presented results suggest the usefulness of the analysis of blood gases and acid-base status in the evaluation and prognosis of various degrees and severity of respiratory diseases in calves, and in monitoring the patient response to treatment. Although plasma lactate analysis is less consistent with the severity of respiratory diseases, it might be helpful in the indication of an untreatable stage of the disease and upcoming death.

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Section: Discussionmentioning

confidence: 67%

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

et al. 2015

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“…Serum protein electrophoresis can provide detailed information about pathological conditions related to protein profile. However, this method is rarely used in the diagnosis of bovine diseases (Apaydın and Dede, 2010;Dede et al 2014;Tóthová et al 2010;Tóthová et al 2013b).…”

Section: Resultsmentioning

confidence: 99%

“…Treatment of pneumonia is likely to increase survival, economic and animal welfare of heifers. There are many different agents in the etiology of respiratory diseases such as H. Somni, M. haemolytica, P. Multocidaetc. The diagnosis of calf pneumonia is based on clinical symptoms such as specific symptoms, depression and body temperature (Alacam and Sahal, 1997;Angen et al 2009;Batra et al 2003;Closs Jr. and Dechow, 2017;Snowder et al 2006;Tóthová et al 2013b;Turgut, 2000).…”

Section: Introductionmentioning

confidence: 99%

Determination of Blood Serum Protein Fractions of Calves with Clinically Diagnosed Pneumonia

Ekici

Dede

Yüksek

et al. 2020

IJAR

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Background: Respiratory diseases in calves are causing worldwide economic losses for the beef industry. This study was planned to determine the serum protein fractions and A/G ratio in calves with clinically diagnosed pneumonia, and evaluate the possibility uses of these parameters as clinical diagnostic parameters.Methods: The 34 calves with respiratory system problems and 10 healthy calves without clinical pneumonia symptoms were used as materials. The obtained serum samples were used for total protein and serum protein electrophoresis.Result: Albumin, α1-globulin percentages and A/G ratio decreased in the patient group (p≤0.01), other globulin fractions were higher in the patient group (p≤0.01), for % g values. According to concentration results, it was found that while albumin did not show a significant difference, α1-globulin (p≤0.05) and A / G ratio (p≤0.01) decreased in the patient group. In addition, other globulin fractions and total protein levels were higher in patient groups (p≤0.01). As a result, the serum protein fractions should be evaluated as a useful biochemical blood parameter for diagnosis and follow up of lung diseases especially in calves.

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“…The flow diagram outlining the selection strategy to obtain 25 articles is summarized in Figure . Twenty‐three studies, , , were ultimately included. Two articles described studies already reported in different journals…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease

Abdallah

Hewson

Francoz

et al. 2016

Veterinary Internal Medicne

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BackgroundBovine respiratory disease (BRD) is a worldwide animal health concern especially in feedlot, dairy, and veal calves. One of the greatest challenges is the absence of a gold standard for achieving an accurate antemortem diagnosis. Various blood markers, including the acute‐phase proteins (AAP), have been proposed as potential valuable tools for BRD diagnosis.ObjectivesTo perform a systematic review of the literature to assess the accuracy of selected APP (haptoglobin [Hp], serum amyloid A [SAA], and fibrinogen [Fb]) as diagnostic tools for cattle with naturally occurring BRD when compared with clinical reference standards of diagnosis.MethodsThis review was performed with eligible studies selected from CAB Abstract and MEDLINE from 1946 to 2015, as well as the “gray literature.” Methodological quality of included studies was assessed using the QUADAS‐2 tool developed for diagnostic accuracy studies. The accuracy parameters sensitivity (Se) and specificity (Sp) were obtained from the articles or through contact with the authors when not directly reported.ResultsA total of 314 studies were identified, from them, 23 met inclusion criteria as diagnostic studies for naturally occurring BRD. Quality of studies showed high risk of bias for case selection (70% of articles) and unclear risk of bias for index test (65%), reference standard (74%), and flow and timing (61%). There were high concerns regarding applicability for case selection (61% of studies) and reference standards used for defining BRD (48%). The concerns regarding index test application were low (83% of the studies). Only 4–8 studies could be included in the meta‐analysis for each APP. No pooled estimates or pooled accuracy measurements were performed due to the low number of studies and multiple differences between studies, including reference standard definitions.Conclusions and Clinical ImportanceOn the basis of these findings, it is not possible to make conclusions regarding the accuracy of APP for BRD diagnosis. The reporting of accuracy of APP for BRD detection is inconsistent among studies. Recommendations to improve capability for future meta‐analyses in this area include reporting studies on diagnostic tests following the Standard for the Reporting of Diagnostic Accuracy Studies (STARD), as well as trying to standardize BRD definition across future studies.

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The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Cited by 11 publications

References 13 publications

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

Determination of Blood Serum Protein Fractions of Calves with Clinically Diagnosed Pneumonia

Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease

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