The SHINE Trial (A Multicentre, Randomised Trial of Stabilisation with Nasal High Flow During Neonatal Endotracheal Intubation): Statistical Analysis Plan

Abstract

Endotracheal intubation is an essential but potentially destabilising procedure for neonates. With an increased focus on avoiding mechanical ventilation, particularly in preterm infants, there are fewer opportunities for clinicians to gain proficiency in this important emergency skill. Rates of successful intubation at the first attempt are relatively low, and adverse event rates including desaturation and bradycardia are high, when compared with intubations in paediatric and adult populations. Interventions to improve operator success and patient stability during neonatal endotracheal intubations are needed. Using nasal high flow therapy during apnoea extends the safe apnoea time of adults undergoing upper airway surgery and during endotracheal intubation [1]. This technique is untested in neonates.