The Short-Term Inhalation Study (STIS) as a Range Finder and Screening Tool in a Tiered Grouping Strategy

Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH

“…As there is no other appropriate OECD test guideline available for such study, we suggest the use of STIS, which has already been used for a decade (Ma-Hock, Burkhardt, et al 2009,) for numerous nanomaterials by various research groups (Ma-Hock et al 2014;Landsiedel et al 2014;Gosens et al 2016;Kim et al 2018). The STIS is currently not a regulatory requirement, but it could markedly reduce animal testing in supporting grouping into sets of similar nanoforms, and regardless of the outcome of grouping, it serves as a dose-range finder which is required in a toxicological testing program for repeated -dose inhalation regulatory studies (Wiench and Ma-Hock 2019).…”