The sigmoid colon and bladder shielding in whole pelvic irradiation at prostate cancer (forward planned IMRT from Institute of Oncology Ljubljana)

Grabec, Daša; Kragelj, Borut

doi:10.2478/v10019-009-0001-4

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…In addition to absolute evaluation, the differences between endpoints for each method were also evaluated. 26 As such, for comparison of prostate matching and bone matching image guidance strategies, ΔD95, defined as prostate D95 for prostate matching minus prostate D95 for bone matching, was determined for each fraction. Defined analogously, bladder ΔD45 and rectum ΔD30 values were also evaluated.…”

Section: Bone Matching Prostate Matchingmentioning

confidence: 99%

Dosimetric implications of two registration based patient positioning methods in prostate image guided radiation therapy (IGRT)

Rivest¹,

Riauka²,

Murtha³

et al. 2009

Radiology and Oncology

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Section: Bone Matching Prostate Matchingmentioning

confidence: 99%

Dosimetric implications of two registration based patient positioning methods in prostate image guided radiation therapy (IGRT)

Rivest¹,

Riauka²,

Murtha³

et al. 2009

Radiology and Oncology

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“…The details of technique have been described elsewhere. 22 The patients were simulated in supine position with knee and feet fixation device and urethrogram, to define prostatic apex. Clinical target volume (CTV) included prostate and distal 2/3 of seminal vesicles with lymph nodes along external, internal and common iliac vessels in patients with Gleason Score (GS) 8–10 or locally advanced tumours, or if the risk of positive lymph nodes (Risk N+ ) exceeded 15% according to the equation of Roach et al ( Equation 1 ).…”

Section: Methodsmentioning

confidence: 99%

Obstructive urination problems after high-dose-rate brachytherapy boost treatment for prostate cancer are avoidable

Kragelj

2016

Radiology and Oncology

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BackgroundAiming at improving treatment individualization in patients with prostate cancer treated with combination of external beam radiotherapy and high-dose-rate brachytherapy to boost the dose to prostate (HDRB-B), the objective was to evaluate factors that have potential impact on obstructive urination problems (OUP) after HDRB-B.Patients and methodsIn the follow-up study 88 patients consecutively treated with HDRB-B at the Institute of Oncology Ljubljana in the period 2006-2011 were included. The observed outcome was deterioration of OUP (DOUP) during the follow-up period longer than 1 year. Univariate and multivariate relationship analysis between DOUP and potential risk factors (treatment factors, patients’ characteristics) was carried out by using binary logistic regression. ROC curve was constructed on predicted values and the area under the curve (AUC) calculated to assess the performance of the multivariate model.ResultsAnalysis was carried out on 71 patients who completed 3 years of follow-up. DOUP was noted in 13/71 (18.3%) of them. The results of multivariate analysis showed statistically significant relationship between DOUP and anti-coagulation treatment (OR 4.86, 95% C.I. limits: 1.21-19.61, p = 0.026). Also minimal dose received by 90% of the urethra volume was close to statistical significance (OR = 1.23; 95% C.I. limits: 0.98-1.07, p = 0.099). The value of AUC was 0.755.ConclusionsThe study emphasized the relationship between DOUP and anticoagulation treatment, and suggested the multivariate model with fair predictive performance. This model potentially enables a reduction of DOUP after HDRB-B. It supports the belief that further research should be focused on urethral sphincter as a critical structure for OUP.

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“…Intensity-modulated radiation therapy (IMRT) involves complex treatment plans that are completely patient specific in order to highly conform delivered dose to the treatment volume, thus improving normal tissue sparing as compared to more traditional radiotherapy techniques. 1 , 2 As a consequence, the complexity and uniqueness of these treatment plans demand patient-specific pretreatment quality assurance (QA) of all IMRT treatments. Standard methods of IMRT QA involve ionization chambers, diode arrays and radiographic films, often used in some combination to provide verification of absolute dose, field geometry, number of monitor units, etc.…”

Section: Introductionmentioning

confidence: 99%

A fully electronic intensity-modulated radiation therapy quality assurance (IMRT QA) process implemented in a network comprised of independent treatment planning, record and verify, and delivery systems

Bailey

Kumaraswamy²,

Podgorsak

2010

Radiology and Oncology

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BackgroundThe purpose of this study is to implement an electronic method to perform and analyze intensity-modulated radiation therapy quality assurance (IMRT QA) using an aSi megavoltage electronic portal imaging device in a network comprised of independent treatment planning, record and verify (R&V), and delivery systems.MethodsA verification plan was generated in the treatment planning system using the actual treatment plan of a patient. After exporting the treatment fields to the R&V system, the fields were delivered in QA mode with the aSi imager deployed. The resulting dosimetric images are automatically stored in a DICOM-RT format in the delivery system treatment console computer. The relative dose density images are subsequently pushed to the R&V system. The absolute dose images are then transferred electronically from the treatment console computer to the treatment planning system and imported into the verification plan in the dosimetry work space for further analysis. Screen shots of the gamma evaluation and isodose comparison are imported into the R&V system as an electronic file (e.g. PDF) to be reviewed prior to initiation of patient treatment. A relative dose image predicted by the treatment planning system can also be sent to the R&V system to be compared with the relative dose density image measured with the aSi imager.ResultsOur department does not have integrated planning, R&V, and delivery systems. In spite of this, we are able to fully implement a paperless and filmless IMRT QA process, allowing subsequent analysis and approval to be more efficient, while the QA document is directly attached to its specific patient chart in the R&V system in electronic form. The calculated and measured relative dose images can be compared electronically within the R&V system to analyze the density differences and ensure proper dose delivery to patients.ConclusionsIn the absence of an integrated planning, verifying, and delivery system, we have shown that it is nevertheless possible to develop a completely electronic IMRT QA process.

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The sigmoid colon and bladder shielding in whole pelvic irradiation at prostate cancer (forward planned IMRT from Institute of Oncology Ljubljana)

Abstract: Background. The whole pelvic irradiation (WPI) is again gaining the important role in radiotherapy of

Cited by 3 publications

References 10 publications

Dosimetric implications of two registration based patient positioning methods in prostate image guided radiation therapy (IGRT)

Dosimetric implications of two registration based patient positioning methods in prostate image guided radiation therapy (IGRT)

Obstructive urination problems after high-dose-rate brachytherapy boost treatment for prostate cancer are avoidable

A fully electronic intensity-modulated radiation therapy quality assurance (IMRT QA) process implemented in a network comprised of independent treatment planning, record and verify, and delivery systems

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