The similarities and differences among patients with abdominal aortic aneurysms referred to a tertiary hospital and found at necropsy

Abstract

Intact abdominal aortic aneurysm at necropsy and at outpatients setting showed similarities that confirmed that abdominal aortic aneurysm repair is less offered to women, and they died more frequently with intact abdominal aortic aneurysm from other causes.

Negative association of diabetes with rupture of abdominal aortic aneurysm

“…Of 100 potentially relevant articles screened initially, nine eligible studies 8,[11][12][13][14][15][16][17][18] were identified. Furthermore, two relevant studies 6,7 were added through a manual search.…”

“…In total, our meta-analysis included 11 studies. [6][7][8][11][12][13][14][15][16][17][18] Study design (Table 1), patient characteristics (Table 1; online Appendices 1 and 2), diabetes prevalence, rupture incidence and relative risk of rupture are summarized in Table 2. In a case-control study by Buijs et al, 11 non-ruptured symptomatic AAA and ruptured AAA were combined and labelled as non-elective AAA.…”

“…In the rupture group of another case-control study by Fillinger et al, 13 emergency AAA repair was performed because of rupture or acute severe pain. As a primary meta-analysis, thus, we combined the remaining nine studies [6][7][8]12,[14][15][16][17][18] reporting data on ruptured (not including non-ruptured symptomatic) AAA. Additionally, all of the 11 studies were combined as a secondary meta-analysis.…”

“…significantly lower AAA-rupture prevalence in diabetes), which was sequentially eliminated in sensitivity analyses to assess their impact on the pooled effect estimate. The primary meta-analysis of the nine studies [6][7][8]12,[14][15][16][17][18] demonstrated that diabetes was associated with significantly lower prevalence/incidence of AAA rupture (i.e. significantly and negatively associated with AAA rupture) (fixed-effects OR/HR, 0.71; 95% CI, 0.56 to 0.89; p = 0.003; Figure 1).…”

“…Multivariate-adjusted ORs/HRs were available in four studies, 14,15,17,18 whereas univariate-unadjusted ORs/HRs only in seven studies. [6][7][8][11][12][13]16 Two 8,16 of these seven studies provided significantly lower diabetes prevalence in AAA rupture (i.e. significantly lower AAA-rupture prevalence in diabetes), which was sequentially eliminated in sensitivity analyses to assess their impact on the pooled effect estimate.…”