The single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto poly(lactic acid) electrospun film on wound-healing

Naseri-Nosar, Mahdi; Salehi, Majid; Farzamfar, Saeed; Azami, Mahmoud

doi:10.1177/0883911517724809

Cited by 35 publications

(10 citation statements)

References 56 publications

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“…The amount of released Met at each designated time point was measured by UV spectrophotometry at the wavelength of 232 nm. The drug release at different time points was evaluated using the following equation The porosities of fabricated fibrous membranes were measured by evaluating the SEM images using ImageJ software, as described in ref . For this reason, four SEM images at different magnifications were used for analyzing and the total percentage of the porosity was calculated (the values are given in the mean and standard deviation).…”

Section: Methodsmentioning

confidence: 99%

Metformin-Loaded PCL/PVA Fibrous Scaffold Preseeded with Human Endometrial Stem Cells for Effective Guided Bone Regeneration Membranes

Ebrahimi

Farzin

Ghasemi

et al. 2020

ACS Biomater. Sci. Eng.

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Many studies have been devoted to investigating the potential of guided bone regeneration (GBR) membranes for bone defect reconstruction. Regardless of approaches for treating damaged bone tissues, a beneficial therapeutic strategy has remained a challenge. In this study, a novel GBR membrane with polycaprolactone (PCL) and poly(vinyl alcohol) (PVA) containing different concentrations of metformin (Met) for improving osteogenic properties was developed. The membranes were evaluated for their hydrophilicity, degradation rate, swelling ratio, drug release, mechanical properties, and biological responses. The results showed a significant increase in hydrophilicity, swelling ratio, and degradation rate and no significant changes in mechanical properties of PCL/PVA membranes with Met concentration enhancement. A decrease in cell viability cultured on the surface of the PCL/PVA membrane was seen when the amount of Met was changed from 10 to 15 wt %. The results of the in vitro quantitative real-time polymerase chain reaction (qRT-PCR) also confirmed the higher secretion of osteogenic-related genes in a PCL/PVA/Cell/10 wt % Met scaffold than in the PCL/PVA/Cell sample. Therefore, further in vivo studies were conducted using the electrospun PCL/PVA membrane containing human endometrial stem cells (hEnSCs) and 10% Met. Histopathological and histomorphometric results confirmed that PCL/PVA/hEnSCs/10 wt % Met has excellent potential to differentiate hEnSCs into osteogenic lineages and bone regeneration in calvarial defects of rats. The results of this study confirm the high potential of the PCL/PVA/10 wt % Met fibrous membrane preseeded with hEnSCs in GBR applications.

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Section: Methodsmentioning

confidence: 99%

Metformin-Loaded PCL/PVA Fibrous Scaffold Preseeded with Human Endometrial Stem Cells for Effective Guided Bone Regeneration Membranes

Ebrahimi

Farzin

Ghasemi

et al. 2020

ACS Biomater. Sci. Eng.

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“…The in vivo wound healing analysis of curcumin-encapsulated chitosan microparticles loaded into electrospun PLA-based films employing full-thickness excisional wounds of rats showed significant wound closure percentage when compared to plain films and sterile gauze. A synergistic effect of curcumin and chitosan resulted in accelerated healing attributed to a high number of transforming growth factor-β in fibroblasts which are useful for the synthesis of collagen bundles cross-linking and improved the wound contraction [ 93 ]. Vimala and co-workers synthesized chitosan-PVA silver nanocomposite films loaded with curcumin.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…The wound healing process involves four sequential phases: haemostasis, inflammatory, proliferative, and maturation phase [ 14 , 15 ]. The haemostasis phase occurs immediately after the injury and is characterized by coagulation of exudate and blood clotting induced by platelets and fibrinogen to control bleeding [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

et al. 2021

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The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.

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The single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto poly(lactic acid) electrospun film on wound-healing

Cited by 35 publications

References 56 publications

Metformin-Loaded PCL/PVA Fibrous Scaffold Preseeded with Human Endometrial Stem Cells for Effective Guided Bone Regeneration Membranes

Metformin-Loaded PCL/PVA Fibrous Scaffold Preseeded with Human Endometrial Stem Cells for Effective Guided Bone Regeneration Membranes

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

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