The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

Abstract

<b><i>Introduction:</i></b> <i>MIR155HG</i> has been found to play an important role in malignant tumors, but little research has been done on its association with esophageal cancer (ESCC). The aim of this study was to investigate the relationship between <i>MIR155HG</i> polymorphisms and ESCC susceptibility in the Chinese Han population. <b><i>Methods:</i></b> 511 ESCC patients and 487 healthy controls were selected for this study. All subjects were genotyped using the Agena MassARRAY platform. We assessed the association between seven single nucleotide polymorphisms (SNPs) of the <i>MIR155HG</i> and ESCC risk by genetic model analysis. The false discovery rate (FDR) test and Bonferroni correction were usually used to detect false positives for the results. Meanwhile, the interaction between SNPs was analyzed by multifactor dimensionality reduction software to predict the ESCC risk. <b><i>Results:</i></b> The C allele of rs4143370 and the A allele of rs34904192 in <i>MIR155HG</i> can increase the risk of ESCC (odds ratio (OR) = 1.33, <i>p</i> = 0.024; OR = 1.30, <i>p</i> = 0.013). Furthermore, rs4143370 and rs34904192 were associated with an increased risk of ESCC. Stratified analysis showed that <i>MIR155HG</i> SNPs (rs4143370 and rs34904192) significantly increased ESCC risk in males. <i>MIR155HG</i> SNPs (rs4143370, rs34904192, and rs928883) were also strongly associated with an increased risk of ESCC in people aged >64 years. In addition, haplotype analysis of the seven SNPs of the <i>MIR155HG</i> showed that the CC haplotype was associated with ESCC risk (OR = 1.34, <i>p</i> = 0.024). <b><i>Conclusion:</i></b> This study revealed that <i>MIR155HG</i> SNPs were associated with an increased risk of ESCC. The results provided clues for clarifying the role of MIR155HG in ESCC.