The size-dependent efficacy and biocompatibility of hyperbranched polyglycerol in peritoneal dialysis

Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

“…HPG (1 kDa) was synthesized by anionic ring opening multi-branching polymerization, and its characteristics were verified as described previously [18, 19]. …”

“…The histological analysis of the submesothelial thickness was performed in hematoxylin and eosin (H&E) stained tissue section as described previously [18]. The number of the blood vessel and capillaries per millimeter of the peritoneum section was counted longitudinally in the PM (both submesothelial and muscle-associated connective tissue layers) of the whole tissue sections.…”

“…Recent reports in literature demonstrate the biocompatibility and potential use of this macromolecule in many different biomedical applications, such as a human serum albumin substitute [14], a drug carrier [15, 16] and a colloid for cold preservation of cells or organs [17]. Our preliminary studies have shown that HPG (0.5–3 kDa)-based PD solutions can be prepared by varying the HPG concentration from 2.5 to 15% (w/v) within an osmolality range (294–424 mOsm/kg) and neutral pH (6.6–7.4) that are comparable to Dianeal (2.5% glucose, 395 mOsm/L, pH 5.2) and PYS (2.27% glucose, 395 mOsm/L, pH 7.4) [18, 19], and by a single dwell time these HPG-based PD solutions produced similar or significantly better fluid and waste removal while causing less damage to peritoneal membrane (PM) in rats compared to either Dianeal (2.5% glucose) or PYS (2.27% glucose) [18, 19]. The objective of the current study was to investigate the long-term effects of HPG-based PD solution (denoted here as HPG) compared to conventional glucose-based PYS in rats, especially on the PM structure and function.…”

The Impact of Dialysis Modality on Novel Markers of Stress Reaction, Matrix Remodeling and Endothelial Damage in Children on Chronic Dialysis

“…Research on biocompatibility focuses both on technical progress, thereby improving the quality of materials [2,3,4], and on exploration of mechanisms underlying CKD- and dialysis-related complications [5,6,7,8]. However, ideal dialyzers, peritoneal fluids or markers of biocompatibility have not been found so far.…”

Hyperbranched polyglycerol nanoparticles based multifunctional, nonmigrating hindered phenolic macromolecular antioxidants: Synthesis, characterization and its stabilization effect on poly(vinyl chloride)

“…Among such highly branched macromolecules, hyperbranched polyglycerol (HbPG) with average diameter in the few nanometer range (~2-20 nm) and with both chain end and pendant hydroxyl functionalities offers a variety of new derivatization processes to obtain materials with advantageous application possibilities, ranging from biomedicine to nanotechnologies and large scale commodities as well [9][10][11][12][13][14][15][16][17][18]. HbPG is a polyether polyol, which has favorable properties, namely low cytotoxicity, biocompatibility, water solubility and low viscosity [19][20][21].…”