The SLC19A1-AS/miR-1343/WNT11 axis is a novel positive regulatory ceRNA network governing goat granulosa cell proliferation

Zhang, Runan; Zhou, Zuyang; Wang, Peng; He, Xiaoyun; Liu, Yufang; Chu, Mingxing

doi:10.1016/j.ijbiomac.2024.130658

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.130658

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The SLC19A1-AS/miR-1343/WNT11 axis is a novel positive regulatory ceRNA network governing goat granulosa cell proliferation

Runan Zhang,

Zuyang Zhou,

Peng Wang

et al.

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Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Tatone,

Di Emidio,

Battaglia

et al. 2024

Antioxidants

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The ovary is a major determinant of female reproductive health. Ovarian functions are mainly related to the primordial follicle pool, which is gradually lost with aging. Ovarian aging and reproductive dysfunctions share oxidative stress as a common underlying mechanism. ROS signaling is essential for normal ovarian processes, yet it can contribute to various ovarian disorders when disrupted. Therefore, balance in the redox system is crucial for proper ovarian functions. In the present study, by focusing on mRNAs and ncRNAs described in the ovary and taking into account only validated ncRNA interactions, we built an ovarian antioxidant ceRNA network, named OvAnOx ceRNA, composed of 5 mRNAs (SOD1, SOD2, CAT, PRDX3, GR), 10 miRNAs and 5 lncRNAs (XIST, FGD5-AS1, MALAT1, NEAT1, SNHG1). Our bioinformatic analysis indicated that the components of OvAnOx ceRNA not only contribute to antioxidant defense but are also involved in other ovarian functions. Indeed, antioxidant enzymes encoded by mRNAs of OvAnOx ceRNA operate within a regulatory network that impacts ovarian reserve, follicular dynamics, and oocyte maturation in normal and pathological conditions. The OvAnOx ceRNA network represents a promising tool to unravel the complex dialog between redox potential and ovarian signaling pathways involved in reproductive health, aging, and diseases.

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Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Tatone,

Di Emidio,

Battaglia

et al. 2024

Antioxidants

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show abstract

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The SLC19A1-AS/miR-1343/WNT11 axis is a novel positive regulatory ceRNA network governing goat granulosa cell proliferation

Cited by 1 publication

References 55 publications

Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions

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