2008
DOI: 10.1113/jphysiol.2008.154468
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The Slc26a4 transporter functions as an electroneutral Cl/I/HCO3 exchanger: role of Slc26a4 and Slc26a6 in I and HCO3 secretion and in regulation of CFTR in the parotid duct

Abstract: − /HCO 3 − exchange by Slc26a6, but had no effect on I − secretion by Slc26a4. Accordingly, deletion of Slc26a6, but not deletion of Slc26a4, results in dysregulation of CFTR. These findings provide the first evidence for a selective role of the SLC26 transporters expressed in the same tissue in epithelial anion transport and suggest that transport specificity is achieved by both the properties of the transporters and the composition of the complexes they form.

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Cited by 134 publications
(126 citation statements)
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“…Sealed parotid ducts were prepared as described in ref. 37. In brief, female mice (20-25 g) were killed by cervical dislocation.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Sealed parotid ducts were prepared as described in ref. 37. In brief, female mice (20-25 g) were killed by cervical dislocation.…”
Section: Methodsmentioning
confidence: 99%
“…As an example, Supplemental Figure 2 shows regulation of NBC activity by IRBIT and the WNKs in sealed parotid duct. Parotid ducts seal after 12-24 hours in culture (37).…”
Section: Role Of the Wnk And Spak Kinases In Vivomentioning
confidence: 99%
“…Intraluminal Cl -and pH of the sealed ducts were measured as we described recently (39). In brief, ducts with inner diameters of 40-60 μm were immobilized with large-bore suction pipettes.…”
Section: Methodsmentioning
confidence: 99%
“…Pendrin consists of 780 amino acids with a predicted cytoplasmic amino terminus and 12 transmembrane spanning regions (1,2). Functional studies show that pendrin mediates electroneutral exchange of Cl 2 with various anions including I 2 , HCO 3 2 , OH 2 , NO 3 2 , SCN 2 (thiocyanate), and HCO 2 2 (formate) (2)(3)(4)(5)(6)(7)(8). In addition to the inner ear and thyroid, pendrin is expressed in the kidney, airways, and adrenal gland (1,4,6,7,(9)(10)(11)(12).…”
mentioning
confidence: 99%