The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite

Okuda, Takatoshi; Ioku, Koji; Yonezawa, Ikuho; Minagi, Hideyuki; Gonda, Yoshinori; Kawachi, Giichiro; Kamitakahara, Masanobu; Shibata, Yasuaki; Murayama, Hisashi; Kurosawa, Hisashi; Ikeda, Tohru

doi:10.1016/j.biomaterials.2008.03.028

Cited by 114 publications

(72 citation statements)

References 21 publications

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“…The calcium-deficient HA ceramic composed of rodshaped particles was synthesized by hydrothermal treatment. 14) This HA ceramic showed better replaceability with bone tissue in rabbit femurs than the pure stoichiometric HA 17) . The calciumdeficiency of this HA ceramic was thought to be important because the Ca/P molar ratio of HA in the bone was reported to be lower than the stoichiometric Ca/P ratio, 1.67.…”

Section: Introductionmentioning

confidence: 92%

Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate

Ito

Kamitakahara

Murakami

et al. 2010

J. Ceram. Soc. Japan

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Hydroxyapatite (HA) particles synthesized by hydrothermal treatment of octacalcium phosphate (OCP) particles were characterized in detail and the reaction mechanism was discussed. The calcium-deficient HA particles were firstly formed and their compositions gradually closed to the stoichiometric composition with reaction progress. While their compositions closed to the stoichiometric composition, split of plate-shaped HA particles into smaller strips and subsequent crystal growth of HA particles were observed. The [001] direction of synthesized HA was parallel to the [001] direction of starting material of OCP. The hydrothermal treatment of OCP particles is useful for synthesis of plate-shaped HA particles with different morphologies and compositions.

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Section: Introductionmentioning

confidence: 92%

Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate

Ito

Kamitakahara

Murakami

et al. 2010

J. Ceram. Soc. Japan

Self Cite

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“…Furthermore, submicron-sized HA powders are biodegraded even faster than the highly porous HA scaffolds. Other examples of bioresorbable materials include porous bioceramic scaffolds made of BCP (which is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) or bone grafts (dense or porous) made of CDHA [152], TCP [411,596,597] and/or ACP [462,598]. One must stress that recently the concepts of bioactive and bioresorbable materials have converged and bioactive materials are made bioresorbable, while bioresorbable materials are made bioactive [599].…”

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…The bottleneck for most CaP formulations, including hydroxyapatite-based formulations, is their poor resorption rate, especially for sintered HA, which is one of the most commonly used materials [10]. In vivo studies have proved that even after 9 months of implantation sintered HA remained at the site with hardly any sign of resorption [11,12]. To circumvent this problem, HA has been combined with more soluble phases such as β-tricalcium phosphate (β-TCP) [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite

Cited by 114 publications

References 21 publications

Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate

Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate

Medical Application of Calcium Orthophosphate Bioceramics

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

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