The small GTPase RAB37 functions as an organizer for autophagosome biogenesis

Song, Ying; Shang, Dantong; Cheng, Hanhua; Zhou, Rongjia

doi:10.1080/15548627.2018.1434374

Cited by 23 publications

(13 citation statements)

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“…However, whether Rho GTPases are required for FSS-induced autophagy remains unclear. A recent report indicated that the small GTPase functioned as an organizer for autophagosome biogenesis 47 . On the contrary, other studies previously reported a negative role of Rho GTPases in regulating autophagy activation 36 .…”

Section: Discussionmentioning

confidence: 99%

Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells

et al. 2018

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The autophagy in cancer cells is recognized as an essential hallmark of tumors, which can enhance cancer cell migration and invasion, and result in high incidence of tumor metastasis. The fluid shear stress (FSS) in tumor mechanical microenvironment plays a pivotal role in mediating the behaviors and functions of cells. In this study, the hepatocellular carcinoma cells were exposed to 1.4 dyn/cm2 FSS to explore whether FSS could induce autophagy. The results of TEM, Ad-mCherry-GFP labeled LC3B, and mRNA and protein expression of autophagy markers confirmed that FSS could induce autophagy in a time-dependent manner. Additionally, the inhibition of autophagy significantly downregulated the expression of PI3K, FAK and Rho GTPases, and attenuated the ability of cell migration, suggesting that FSS-induced autophagy depended on PI3K- FAK-Rho GTPases pathway. This study elucidated the role of FSS in inducing autophagy during tumor progression, which has emerged as a promising clinical strategy for cancer.

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Section: Discussionmentioning

confidence: 99%

Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells

et al. 2018

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“…Rab GTPases regulate vesicular traffic events, including vesicle tethering, transport, and fusion. Several Rabs have been associated with the induction of autophagy (Rab18 and Rab37) [ 34 , 35 ] and regulate autophagosome biogenesis from the endoplasmic reticulum (Rab1, Rab5, and Rab32) and the Golgi apparatus (Rab33B) or facilitate the fusion of multivesicular bodies or recycling endosomes with the autophagosome (Rab11, Rab12, and Rab23) [ 36 , 37 ].…”

Section: The Rab Gtpase Network In Autophagymentioning

confidence: 99%

“…Rab18 has been characterized as a positive regulator of early autophagy in human fibroblasts and is dependent on Rab3GAP1/2, which is a RabGEF for Rab18 [ 34 ]. Activated Rab37 has been implicated in the formation of phagophores upon the induction of autophagy via interactions with the ATG5-12/16L complex to promote the elongation of isolation membranes and expression of LC3-II [ 35 ].…”

Section: The Rab Gtpase Network In Autophagymentioning

confidence: 99%

Rab GTPases in Osteoclastic Bone Resorption and Autophagy

Roy

Roux

2020

IJMS

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Small guanosine triphosphate hydrolases (GTPases) of the Rab family are involved in plasma membrane delivery, fusion events, and lysosomal and autophagic degradation pathways, thereby regulating signaling pathways and cell differentiation and function. Osteoclasts are bone-resorbing cells that maintain bone homeostasis. Polarized vesicular trafficking pathways result in the formation of the ruffled border, the osteoclast’s resorptive organelle, which also assists in transcytosis. Here, we reviewed the different roles of Rab GTPases in the endomembrane machinery of osteoclasts and in bone diseases caused by the dysfunction of these proteins, with a particular focus on autophagy and bone resorption. Understanding the molecular mechanisms underlying osteoclast-related bone disease development is critical for developing and improving therapies.

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“…Rab37 has also been implicated in phagophore formation upon induction of autophagy. Specifically, in the GTP-bound state, Rab37 reportedly interacted with Atg5 and recruited Atg5-12/16L complexes to promote elongation of isolation membranes and LC3-II expression [ 66 , 67 ].…”

Section: Roles Of Rab Gtpases and Their Regulators In Autophagymentioning

confidence: 99%

Rab GTPases in Osteoclastic Endomembrane Systems

Roy

Roux

2018

BioMed Research International

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Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis.

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The small GTPase RAB37 functions as an organizer for autophagosome biogenesis

Cited by 23 publications

References 0 publications

Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells

Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells

Rab GTPases in Osteoclastic Bone Resorption and Autophagy

Rab GTPases in Osteoclastic Endomembrane Systems

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