The small heat shock protein Hsp12.1 has a major role in the stress response and virulence of Cryptococcus gattii

Motta, Heryk; Reuwsaat, Júlia Catarina Vieira; Squizani, Eamim Daidrê; Camargo, Matheus da Silva; Garcia, Ane Wichine Acosta; Schrank, Augusto; Vainstein, Marilene Henning; Staats, Charley Christian; Kmetzsch, Lívia

doi:10.1016/j.fgb.2023.103780

Cited by 3 publications

(2 citation statements)

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“…In A. nidulans, these sHSPs are involved in various conditions such as thermal/cold, osmotic, and oxidative stress [99]. In C. gattii, Hsp12 is also involved in virulence and phagocytosis, demonstrating its importance during infection [101]. In Schizosaccharomyces pombe, heat shock treatment increased the expression of hsp16 by 64-fold in wild-type cells and 141-fold in cdc22-M45 (ribonucleotide reductase) mutant cells [102].…”

Section: Small Hspsmentioning

confidence: 99%

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Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections

Neves-da-Rocha,

Santos-Saboya,

Lopes

et al. 2023

Microorganisms

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Fungi are a diverse group of eukaryotic organisms that infect humans, animals, and plants. To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host’s unique environment, e.g., changes in temperature, pH, and nutrient availability. Appropriate protein folding, assembly, and degradation are essential for maintaining cellular homeostasis and survival under stressful conditions. Therefore, the regulation of proteostasis is crucial for fungal pathogenesis. The heat shock response (HSR) is one of the most important cellular mechanisms for maintaining proteostasis. It is activated by various stresses and regulates the activity of heat shock proteins (HSPs). As molecular chaperones, HSPs participate in the proteostatic network to control cellular protein levels by affecting their conformation, location, and degradation. In recent years, a growing body of evidence has highlighted the crucial yet understudied role of stress response circuits in fungal infections. This review explores the role of protein homeostasis and HSPs in fungal pathogenicity, including their contributions to virulence and host–pathogen interactions, as well as the concerted effects between HSPs and the main proteostasis circuits in the cell. Furthermore, we discuss perspectives in the field and the potential for targeting the components of these circuits to develop novel antifungal therapies.

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Section: Small Hspsmentioning

confidence: 99%

Section: Heat Shock Proteinsmentioning

confidence: 99%