2005
DOI: 10.1016/j.neulet.2004.12.037
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The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia

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Cited by 82 publications
(49 citation statements)
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“…Previously, elevated serum triglyceride levels and body weight gain have been described in patients with polymorphism in the human Snap25 gene, although, notably, these patients had received antipsychotic treatment for schizophrenia (31,32). The hypothalamus controls hepatic lipid metabolism and storage via the autonomic nervous system (52,53).…”
Section: (E and F) Hypothalamic Pstat3 Is Decreased In All Experimentmentioning
confidence: 99%
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“…Previously, elevated serum triglyceride levels and body weight gain have been described in patients with polymorphism in the human Snap25 gene, although, notably, these patients had received antipsychotic treatment for schizophrenia (31,32). The hypothalamus controls hepatic lipid metabolism and storage via the autonomic nervous system (52,53).…”
Section: (E and F) Hypothalamic Pstat3 Is Decreased In All Experimentmentioning
confidence: 99%
“…Normal expression levels of total SNAP-25 appear to be critical for precise synaptic function (27,28), and a reduction affects SNARE protein assembly and synaptic plasticity and even can cause neurodegeneration (28, 29). Even if both SNAP-25 splice variants mediate fast Ca 2+ -triggered release, SNAP-25b-containing SNARE complexes are believed to have a higher degree of stability and therefore increase the pool of primed vesicles, resulting in release dynamics different from those involving 30).Polymorphisms in the human Snap25 gene have been associated with weight gain after antipsychotic treatment, with altered levels of serum triglycerides (31,32), and also with the severity of the metabolic syndrome in T2D (33). Furthermore, polymorphisms in genes expressing proteins directly interacting with SNAP-25 have been implicated in childhood obesity, impaired glucose metabolism and obesity, age of onset of T2D, and insulin requirement in T2D (34-36).…”
mentioning
confidence: 99%
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“…263 The authors argue that CYP2D6 slow metabolism may lead to increased olanzapine concentrations and exposure to weight gain triggers. Polymorphisms in the SNAP-25 gene that codes for a protein involved in synaptic protein have been reported to be marginally associated with weight gain and also to antipsychotic response, 275 although this finding requires confirmation due to the limited size and heterogeneity of the study sample. There is no strong genetic evidence connecting histamine variants with treatment-related weight gain nor with other serotonin (5-HT2A, 5-HT6) or dopamine receptors (D2), G-protein-related proteins (GNB3) and metabolic enzymes (CYP2D6).…”
Section: Prediction Of Side Effectsmentioning
confidence: 99%
“…Three different single nucleotide polymorphisms (SNP; MnlI, TaiI and DdeI in the 3 0 -untranslated region) were chosen for the present analysis as they have been associated with cognitive dysfunction, as well as antipsychotic induced weight gain in schizophrenic patients and attention deficit hyperactivity disorders Musil et al 2008;Kim et al 2007;Müller et al 2005;Mill et al 2004;Brophy et al 2002;Kustanovich et al 2003;Barr et al 2000).…”
Section: Introductionmentioning
confidence: 99%