This study aims to explain how specific regional innovation systems (RISs) play relative important role in the knowledge network within European regions. EC encourages the interactions between regions and develop toward a cohesion balance. The whole Europe can be taken as a knowledge network that consists of different RISs possessing diversified resources. The existences of hierarchical relationships between different regions seem to lead us to explain whether the path toward higher-order position can be done by RISs to shape the regional competence in specific technological fields. We establish the datasets on the basis of patent data (from EPO) and REGIO database. Regional-level dataset, including 129 regions, helps to explore how different RIS develop their technological paths, and whether locational economic factors, technological conditions, and local innovativeness help RISs toward high-order position in the network. In addition, we also explore the role of the interaction of local factors for RISs in developing network position in Europe.