The specific activity of proteins involved in iron metabolism depends on compensation of type 2 diabetes mellitus

Abstract

Objective. We aimed to analyze the alterations of activity of iron metabolism members i.e. ceruloplasmin (Cp) and transferrin (Tf), in relation to the percentage of glycated hemoglobin. The latter is one of biochemical criteria of chronic hyperglycemia compensation in case of type 2 diabetes mellitus.
 Materials and methods. Concentration and activity of Cp and Tf, concentration of iron, copper and lipoprotein cholesterol were measured by biochemical methods in blood serum samples obtained from healthy donors and patients with type 2 diabetes mellitus divided in three groups according to glycated hemoglobin level.
 Results. The significant decrease in serum copper, ferroxidase activity of Cp and iron-binding capacity of Tf, as well as an increase of Tf concentration, in groups with compensated and uncompensated type 2 diabetes mellitus was found.
 Conclusion. Our data demonstrate a statistical link between the degree of type 2 diabetes mellitus compensation and alteration of iron metabolism members’ activity. Thus, an increase of hyperglycemia is associated with a decrease of both Cp ferroxidase activity and the degree of Tf saturation with iron. These alterations may explain the efficiency of treatment with iron chelators of such type 2 diabetes mellitus complications as trophic ulcers. The said disease condition is directly connected with the changes in iron efflux.

Effect of Atherosclerosis Developed from Diabetes on Ceruloplasmin Concentration, Ceruloplasmin Ferroxidase Activity and its Specific in Sera of Diabetic Iraqi Patients with Atherosclerosis

“…also, hyperglycemia increases the concentrations of Cp and a drop in its sp. act 28 . A study which was first to research the relationship of Cp activity with VHD found that the patients had significantly elevated Cp ferroxidase activity 29 .…”