2021
DOI: 10.1093/nar/gkab649
|View full text |Cite
|
Sign up to set email alerts
|

The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation

Abstract: Gene expression is finely and dynamically controlled through the tightly coordinated and interconnected activity of epigenetic modulators, transcription and splicing factors and post-translational modifiers. We have recently identified the splicing factor SLU7 as essential for maintaining liver cell identity and genome integrity and for securing cell division both trough transcriptional and splicing mechanisms. Now we uncover a new function of SLU7 controlling gene expression at the epigenetic level. We show t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
9
0
6

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(15 citation statements)
references
References 70 publications
(113 reference statements)
0
9
0
6
Order By: Relevance
“…Speckles are nuclear structures enriched in pre-mRNA splicing factors that generally co-localize with actively transcribed chromatin regions [ 32 ]. Accordingly, Western blot analyses after subcellular fractionation revealed an enrichment of SLU7 bound to chromatin [ 18 , 19 ]. As mentioned above, the NLS, the zinc knuckle motif and the lysine-rich domain of SLU7 dictate this predominantly nuclear localization [ 22 ].…”
Section: Characterization Of Slu7mentioning
confidence: 99%
See 4 more Smart Citations
“…Speckles are nuclear structures enriched in pre-mRNA splicing factors that generally co-localize with actively transcribed chromatin regions [ 32 ]. Accordingly, Western blot analyses after subcellular fractionation revealed an enrichment of SLU7 bound to chromatin [ 18 , 19 ]. As mentioned above, the NLS, the zinc knuckle motif and the lysine-rich domain of SLU7 dictate this predominantly nuclear localization [ 22 ].…”
Section: Characterization Of Slu7mentioning
confidence: 99%
“…Surprisingly, we found that SLU7 regulates DNA methylation ( Figure 4 A) and, therefore, SLU7 silencing in a wide variety of cancer cells, resulting in a general DNA hypomethylation [ 18 ]. Mechanistically, we showed that SLU7 is required to secure DNMT1 protein stability and, therefore, a correct DNA methylation inheritance in proliferating cells.…”
Section: Slu7 Regulates Gene Expression At Different Levelsmentioning
confidence: 99%
See 3 more Smart Citations