The spongiotic reaction pattern

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00006-1

Cited by 13 publications

(19 citation statements)

References 948 publications

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“…In eczematous processes, the presence of parakeratosis suggests that the disease has been ongoing for some time, thus allowing the establishment of abnormal maturation of the epidermis. In most cases, parakeratosis in this setting does not show any specific pattern, and can be seen overlying foci of spongiosis in a somewhat haphazard fashion . The presence of variable spongiosis and irregular epidermal acanthosis are the other main features pointing to the diagnosis.…”

Section: Parakeratosismentioning

confidence: 94%

“…When present in multiple small foci, it has been called ‘staccato parakeratosis’ . Additional features in PR include acanthosis (usually mild to moderate), focal spongiosis, exocytosis of lymphocytes (occasionally forming aggregates simulating Pautrier's microabscesses) and extravasation of red blood cells in the papillary dermis …”

Section: Parakeratosismentioning

confidence: 99%

“…Erythema annulare centrifugum also displays focal parakeratosis, and it may be very difficult to distinguish it from PR on histopathological grounds alone. The process is more localized, and the infiltrate is typically described as more tightly cuffed surrounding the superficial vascular plexus, although this might not always be the case . Similar to pityriasis rosea, the pattern of focal parakeratosis may explain the thin trailing scale observed clinically in erythema annulare centrifugum.…”

Section: Parakeratosismentioning

confidence: 99%

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‘Hints’ in the horn: diagnostic clues in the stratum corneum

et al. 2017

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Review'Hints' in the horn: diagnostic clues in the stratum corneumThe stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. We herein review a selection of common and rare entities in which the horny layer may reveal significantly important hints for the diagnosis. These clues include parakeratosis and its different patterns (focal, confluent, alternating, associated with spongiosis, epidermal hyperplasia or lichenoid changes), subcorneal acantholysis, infectious organisms in the stratum corneum (including fungal, bacterial and parasitic), thickening or thinning of the stratum corneum and the presence of different kinds of pigment. Even when normal, the horny layer may prove to be useful when seen in association with severe epidermal damage, a combination of features testifying to the acute nature of the underlying pathological process.Keywords: histopathology, hyperkeratosis, hypokeratosis, parakeratosis, stratum corneum Cardoso JC, Veraitch O, Gianotti R, Ferrara G, Tomasini CF, Singh M, Zalaudek I, Stefanato CM. 'Hints' in the horn: diagnostic clues in the stratum corneum.

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Section: Parakeratosismentioning

confidence: 94%

Section: Parakeratosismentioning

confidence: 99%

Section: Parakeratosismentioning

confidence: 99%

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‘Hints’ in the horn: diagnostic clues in the stratum corneum

et al. 2017

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“…14,18 In addition to chronic irritant dermatitis producing proliferative phenotype prone to HPV infection, [30][31][32] scarring and secondary lymphostasis likely augmented this predisposition by producing an environment with altered immune functions. 35 Most nodules in this histologic setting are similar to those seen in prurigo nodularis or picker's nodules. 33,34 Table 1 lists the demographic and clinicopathologic findings from reported cases of CPD.…”

Section: Discussionmentioning

confidence: 85%

Collapsing Angiokeloidal Dermatofibroma

Schnebelen

Brown²,

Cheung

et al. 2012

The American Journal of Dermatopathology

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A heterogeneous group of benign fibrohistiocytic lesions has been assembled under the umbrella term, dermatofibroma. These lesions share a morphology of bland spindled cells encompassed by and intercalating through thick dermal collagen; unique variants have been described based on secondary histologic features, some of which include aneurysmal, myxoid, lipidized, signet ring, angiomatous, and keloidal. Here, we present a distinct dermatofibroma variant henceforth known as collapsing angiokeloidal dermatofibroma identified in 2 patients with slowly growing nodules of the buttock and the arm. Microscopically, the lesions have a characteristic dermatofibroma appearance but are accompanied by unusual diffuse small caliber vessels whose walls are collapsed by a thick, eosinophilic, keloid-like substance. The eosinophilic material resembles the adjacent dermal collagen; however, it does not stain for type-4 collagen or type-1 procollagen, amyloid, or glycogen. Although the exact composition of the keloidal material remains ambiguous, the architectural novelty of collapsing angiokeloidal dermatofibroma serves to further expand the morphologic spectrum of benign fibrous histiocytomas, although highlighting the difficulty in distinguishing between it and similar lesions.

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“…9 Pityriasis rosea has been reported in all ages, but occurs predominantly between 15 and 35 years. 10 The cause is unknown, although a viral etiology is suspected, especially human herpesvirus-6 and 7 (HHV-6, HHV-7), as most affected patients will not relapse in their lifetime which suggests immunity against the virus. The possibility that our patient had coexisting pityriasis rosea and Hodgkin lymphoma is unlikely, due to the presence of cutaneous macules and plaques, the fact that the patient's rash did not follow the skin lines as pityriasis rosea does, the presence microscopically of neutrophils and interface changes in the skin biopsy, neither of which is a feature of pityriasis rosea, and the resolution of the eruption with treatment for Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Pityriasis rosea-like cutaneous eruption as the presenting symptom of Hodgkin lymphoma. Case report and review of the literature.

Vrotsos

Dosal

Zaiac

et al. 2015

J Dermatol Case Rep

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Background: Cutaneous involvement by Hodgkin lymphoma is extremely rare and usually follows extensive involvement of the lymph nodes. Cutaneous manifestations of Hodgkin lymphoma may be divided into specific and non-specific. Generalized pruritus is one of the most common non-specific presentations of Hodgkin lymphoma as is cutaneous granulomas. Such signs and symptoms should prompt thorough physical exam, including evaluation of lymph nodes, especially in a young patient. Main observation: We report a case of a 22-year-old man who presented with night sweats, weight loss, dry cough, and generalized maculopapular eruption that started with a large patch in the center of the chest and spread to the extremities. Biopsy of the rash revealed pityriasis rosea-like findings. A computerized tomography scan of the chest revealed a mediastinal mass. Biopsy of the mediastinal mass revealed Reed-Sternberg cells in a fibrotic background, diagnostic of Hodgkin lymphoma, nodular sclerosis type. Conclusion:In conclusion, the presentation of Hodgkin lymphoma as a pityriasis rosea-like cutaneous eruption is rare and clinicians should be aware of this presentation. In this paper we review the non-specific cutaneous manifestations of Hodgkin lymphoma in an effort to raise awareness of the diversity of early cutaneous signs of Hodgkin lymphoma. (J Dermatol Case Rep. 2015; 9(3): 81-84)

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The spongiotic reaction pattern

Cited by 13 publications

References 948 publications

‘Hints’ in the horn: diagnostic clues in the stratum corneum

‘Hints’ in the horn: diagnostic clues in the stratum corneum

Collapsing Angiokeloidal Dermatofibroma

Pityriasis rosea-like cutaneous eruption as the presenting symptom of Hodgkin lymphoma. Case report and review of the literature.

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