The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases

Abstract

The findings suggest a possible role for ultraviolet radiation and chronic immunosuppression in the induction of malignant squamous differentiation in a subset of EPCs. Further reports on this histological variant of EPC are required to determine whether a pathogenetic link does indeed exist or whether these tumours simply represent a unique variant of squamous cell carcinoma with divergent acrosyringial differentiation.

An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma

“…Eccrine porocarcinoma is a relatively uncommon cutaneous malignancy with a frequency of 0.005% to 0.01%, and to date, approximately 300 cases have been reported [1][2][3][4][5][6]. Although the histologic appearance of cutaneous squamous cell carcinoma (SCC) is often not a diagnostic dilemma, in tumors that are not well differentiated, the presence of acantholysis, a pseudoglandular appearance, and entrapped glands within tumoral islands (reminiscent of ductal differentiation) generate a differential diagnosis that includes porocarcinoma.…”

Sporotrichoid Metastases to the Skin From Cutaneous Squamous Cell Carcinoma in an Immunocompetent Patient

“…10 The differential diagnosis between SCC and EPC is required due to the different behavior of the 2 neoplasms, with a considerably higher risk for local recurrence, nodal metastases, systemic spread and mortality for the latter versus the former neoplasm. In our case, the very aggressive behavior of the neoplasm required specific immunohistochemical staining to rule out the possibility of an EPC, squamous variant, and to confirm the diagnosis of SCC of the skin.…”

Eccrine porocarcinoma of the scalp

“…Mitoz ve tümör kalınlığının prognostik önemi bulunmadığını bildiren araştırıcılar da vardır (20). Duktal diferansiyasyon alanları CEA ve EMA immunohistokimyaları ile gösterilebilir (4,5,21). S100 ile neoplastik hücreler negatift ir (21,22,23).…”

“…Tümörlerin yarısı önceden var olan ekrin poromanın malign transformasyonu sonucu gelişmektedir. Etiyolojik faktörler; ultraviyole, radyasyon, hematolojik hastalıklar, organ transplantasyonu ve immünsupresyondur (4,5,6).…”