The Src homology and collagen A (ShcA) adaptor protein may participate in the pathogenesis of membranous lupus nephritis

Abstract

The Src homology and collagen A (ShcA) adaptor protein that binds to tyrosine kinase receptors. ShcA plays a role in insulin signaling, stress resistance and energy metabolism. The 66-kDa Src homology 2 domain-containing protein (p66shc) belongs to the ShcA family and has been associated with reactive oxygen species (ROS); increased ROS is involved in the pathology of lupus nephritis (LN). However, whether ShcA can act as a biomarker for oxidative injury in LN is unknown. This study is aimed to investigate the ShcA expression in kidney tissues from patients presenting with LN and the association between ShcA expression and clinical parameters. Renal biopsy tissues were obtained from 62 LN, 20 primary membranous nephropathy (MN) and 10 other secondary MN patients. ShcA was measured by immunofluorescence. The expression of ShcA in the membranous lupus nephritis (class V) group showed a higher trend but there were no significant differences compared with pure mesangial disease (class II) and proliferative (Class III/IV) lupus nephritis. ShcA deposits were negative in primary and other secondary MN. ShcA might act as a new biomarker and a diagnostic tool to identify membranous lupus nephritis with other MN.

Identification of hub ferroptosis-related genes and immune infiltration in lupus nephritis using bioinformatics

“…Excessive production of ROS and down-regulation of antioxidant system components also predispose to ferroptosis 34 . p66shc belongs to the SRC homology and collagen A ( ShcA ) family, a protein associated with ROS generation and capable of induced intracellular ROS production 35 . Thus, SRC may influence the process of ferroptosis by causing an imbalance in the antioxidant system or overproduction of ROS, then participating in the pathogenesis of LN.…”

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

“…Therefore, pan-cancer analysis is essential for the early diagnosis of tumors and the development of biomarkers. SHC1, a cytoplasmic signaling protein, plays a crucial role in transmitting receptor tyrosine kinase signals, insulin signaling, regulating reactive oxygen species (ROS), stress resistance, energy metabolism, cell apoptosis, and cell apoptosis senescence ( Faisal et al, 2002 ; Bhat et al, 2015 ; Abou-Jaoude et al, 2018 ; Cao et al, 2018 ; Zhang et al, 2019 ; Hwang et al, 2020 ). Recent studies have shown that SHC1 is associated with several clinical diseases, especially in tumor development and progression ( Falco et al, 2005 ; Smith et al, 2006 ; Ahn et al, 2017b ; Chao et al, 2019b ; Huang et al, 2019 ; Wright et al, 2019 ; Borah and Bhowmick, 2020 ; Kiepas et al, 2020 ).…”