Annotation. In the 20th century cardiovascular diseases (CVD) is remain a leading global public health problem. The aim of the study was to analyze the general trends and regional characteristics of mortality from CVD in Ukraine in 2010-2020. The dynamic analysis covered the period 2010-2020 and carried out using indicators of absolute growth and growth rate. Regional differentiation of mortality rates from CVD in Ukraine was assessed by the amplitude of a series of regional distribution of indicators, upper and lower quartiles, and the coefficient of regional variation. The stability of territorial characteristics of mortality from CVD was determined using the correlation coefficient (Pearson, r), calculated based on regional indicators in 2010 and 2020. Comparison of age-standardized mortality rates from CVD in Ukraine and countries of Europe and the European Union was carried out based on materials obtained from the statistical database of the international epidemiological study "Global Burden of Disease (GBD)", updated for 2019. It has been established that CVD cause 66.2% of all deaths and CVD are significant medical, social and economic problem for Ukraine. Every day more than 1000 people die from CVD, and 100 of them are of working age. In 2020 408,163 Ukrainians died from this cause, and during 2010-2020, Ukraine lost almost 4.6 million of its inhabitants due to this cause. Almost 70% of these losses are caused by coronary heart disease and 20% by cerebrovascular disease. Age-standardized mortality rates from CVD in Ukraine exceed similar indicators in European countries by 2.5 times, and in EU countries by 3.7 times, and from coronary artery disease – by 3.4 and 5.4 times, respectively. Ukraine lags far behind in terms of the rate of decline in standardized mortality rates from European countries. The regions of Ukraine are characterized by a significant regional variation and a stable territorial profile of mortality from CVD with the concentration of its maximum levels in the most demographically old regions in terms of age composition. The Ukrainian strategy for the prevention of mortality from CVD should be comprehensive, regionally differentiated, depending on the territorial characteristics of the morbidity and mortality from CVD, and combine population-based approach for controlling modified risk factors for CVD with modern methods of secondary and tertiary prevention of CVD, which proven to be effective in European countries with positive experience of prevention of premature death from CVD.