The stiffness and phase frequency response of taenia coli smooth muscle: Comparison of the step and sinusoidal perturbation analysis

Çömelekoğlu, Ülkü; Öztürk, Necla

doi:10.1016/j.medengphy.2007.04.007

Cited by 1 publication

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References 33 publications

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“…The dip or minimum of the plot of stiffness vs frequency of oscillation represents the cross-bridge cycling rate [14], and has been demonstrated to occur at 10-13 Hz for frog sartorius muscle [21], 10 Hz for rabbit psoas muscle [14] and 1-2 Hz for cardiac papillary muscle [22]. Ozturk's group [23] found that stiffness and phase frequency characteristics of taenia coli smooth muscle were similar to cardiac and skeletal muscle, and these investigators detected a dip (minimum) in the stiffness vs frequency relationship of 0.0012 Hz. On the other hand, the behavior of the stiffness and phase vs frequency of oscillation was different in our experiments.…”

Section: Discussionmentioning

confidence: 99%

A dynamic approach reveals non‐muscle myosin influences the overall smooth muscle cross‐bridge cycling rate

et al. 2010

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a b s t r a c tRecent evidence suggests that non-muscle myosin IIB (NMIIB) contributes to smooth muscle contraction. This study was designed to determine the effects of NMIIB on the cross-bridge cycling rate. The cross-bridge cycling rate was investigated using sinusoidal analysis. Frequency analysis revealed two asymptotes in the Bode plot of the data; and the intersection of the asymptotes (corner frequency) was higher for the B +/À strain (8.73 ± 1.10 Hz vs 16.56 ± 1.26 Hz, P < 0.05), consistent with a higher overall cross-bridge cycling rate in heterozygous NMIIB KO (B +/À ) vs WT mice. These results demonstrate that because of their long duty cycle, NMIIB cross-bridges act as an internal load on smooth muscle myosin to decrease the overall cross-bridge cycling rate and muscle V max during force maintenance.

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