The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

Ichino, Naohiro; Osakabe, Keisuke; Sugimoto, Keiko; Yokoi, Akira; Inoue, Takashi; Suzuki, Kôji; Kusuhara, Yoshito; Hamajima, Nobuyuki; Takai, Hiroji; Hata, Tadayoshi

doi:10.1007/s10396-011-0323-x

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…Ultrasound examination was performed during the health check-up to measure the intima-media thickness (IMT) and determine plaque formation in carotid arteries. The results of the ultrasound examinations were reviewed mutually by two or three well-trained ultrasonographers after the health check-up to improve reliability; the details of this procedure have been described elsewhere [ 15 ]. We measured the maximum (max) IMT in both the right and left common carotid arteries (CCA), approximately 20 mm from the bifurcation, as recommended in the guidelines for the ultrasound evaluation of carotid artery lesions [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

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Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

Fujii

Ueyama

Aoi

et al. 2018

Environ Health Prev Med

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BackgroundThe effect of the redox state of human serum albumin (HSA) on the antioxidant properties of the entire body has been a focus of recent research. The usefulness of HSA redox state as a biomarker for reducing oxidative stress has been investigated in clinical settings; however, evidence for its significance as a health index in non-clinical settings is yet to be established. This study aimed to examine the associations between HSA redox state and the atherosclerotic indices of carotid intima-media thickness (IMT) and plaque formation in a rural Japanese population.MethodsWe conducted a cross-sectional study as part of a health check-up program in the rural area of Hokkaido, Japan, at the end of August 2013. A total of 281 residents (124 men and 157 women) were included in the final analysis. Lifestyle-related data were obtained through a self-reported questionnaire, and ultrasound examinations were performed to measure IMT and determine plaque formation. The high-performance liquid chromatography postcolumn bromocresol green method was used to separate HSA into human nonmercaptalbumin and human mercaptalbumin (HMA).ResultsWe found a significant negative relationship between the fraction of HMA [f(HMA)] and IMT (standardized β = − 0.132, p = 0.03). Moreover, f(HMA) was significantly associated with plaque formation (p < 0.01) with an odds ratio of 0.89 (95% confidence interval, 0.81–0.97) for every 10% increment in f(HMA).ConclusionsWe found that the HSA redox state, as determined by f(HMA), was associated with atherosclerotic indices in Japanese subjects. These results suggest that the HSA redox state indicates the risk of developing atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

“…The mean value of the right and left max IMT was used for subsequent statistical analyses. The occurrence of plaques was defined as a focal raised lesion in either the right or left CCA, based on similar definitions used in earlier studies [ 15 , 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

Fujii

Ueyama

Aoi

et al. 2018

Environ Health Prev Med

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“…The higher SI value of bilateral common carotid arteries was used to assess arterial stiffness. This approach could reflect more accurately the severity of arterial stiffness than one-side artery and has been used in previous studies [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study

Peng

Zhu

Yeh

et al. 2016

Aging

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Telomere length, a marker of biological aging, has been associated with cardiovascular disease (CVD). Increased arterial stiffness, an indicator of arterial aging, predicts adverse CVD outcomes. However, the relationship between telomere length and arterial stiffness is less well studied. Here we examined the cross-sectional association between leukocyte telomere length (LTL) and arterial stiffness in 2,165 American Indians in the Strong Heart Family Study (SHFS). LTL was measured by qPCR. Arterial stiffness was assessed by stiffness index β. The association between LTL and arterial stiffness was assessed by generalized estimating equation model, adjusting for sociodemographics (age, sex, education level), study site, metabolic factors (fasting glucose, lipids, systolic blood pressure, and kidney function), lifestyle (BMI, smoking, drinking, and physical activity), and prevalent CVD. Results showed that longer LTL was significantly associated with a decreased arterial stiffness (β=-0.070, P=0.007). This association did not attenuate after further adjustment for hsCRP (β=-0.071, P=0.005) or excluding participants with overt CVD (β=-0.068, P=0.012), diabetes (β=-0.070, P=0.005), or chronic kidney disease (β=-0.090, P=0.001). In summary, shorter LTL was significantly associated with an increased arterial stiffness, independent of known risk factors. This finding may shed light on the potential role of biological aging in arterial aging in American Indians.

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“…Anthropometric measurements of the body height and weight were obtained and used to calculate the body mass index (BMI, kg/m 2 ). Ultrasound examinations were performed to measure the intima-media thickness (IMT) and to determine plaque formation in the carotid arteries as described [32][33][34][35] . The mean value of the right and left max IMT was used for the statistical analyses.…”

Section: Protocols General Examinations Related To Current Studymentioning

confidence: 99%

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

Inooka

Kominami

Yasuda

et al. 2022

Preprint

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The purpose of this study was to determine the ocular, sex- and age-specific, anthropometric, and hematologic factors that affect the implicit times and amplitudes of the flicker ERGs recorded with the RETeval system from individuals 40- to 89-years-of-age. Flicker ERGs were recorded with the RETeval system from 330 individuals who had normal fundus and OCT images. Univariate and multivariate regression analyses were performed to identify factors associated with the implicit times and amplitudes of the RETeval flicker ERGs. Univariate regression analyses showed significant correlations between the implicit times and the BCVA, age, axial length, blood sugar level, and BUN in both eyes. Multivariate regression analyses identified age and axial length as two independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariate regression analyses also showed significant correlations between the amplitudes and age, platelet count, HDL level, and creatinine level in both eyes. However, smoking habits, body mass index, and blood pressure were not correlated with the RETeval flicker ERGs. We conclude that age and some ophthalmologic and hematologic findings except for anthropometric findings were suggested to significantly affect the measurements of the RETeval flicker ERGs.

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The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

Abstract: The stiffness parameter β is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.

Cited by 8 publications

References 29 publications

Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

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