2024
DOI: 10.1371/journal.pone.0299640
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The stringent response regulates the poly-β-hydroxybutyrate (PHB) synthesis in Azotobacter vinelandii

Cristian Camilo Ortiz-Vasco,
Soledad Moreno,
Luis Alonso Quintero-Navarro
et al.

Abstract: The stringent response exerted by (p)ppGpp and RNA-polymerase binding protein DksA regulates gene expression in diverse bacterial species. To control gene expression (p)ppGpp, synthesized by enzymes RelA and SpoT, interacts with two sites within the RNA polymerase; site 1, located in the interphase between subunits β’ and ω (rpoZ), and site 2 located in the secondary channel that is dependent on DksA protein. In Escherichia coli, inactivation of dksA results in a reduced sigma factor RpoS expression. In Azotob… Show more

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