Background. One of the important areas of pharmaceutical research is the creation of new, as well as improvement of existing, in-demand dosage forms, using already known drugs as active substances. Current issues are the development of drugs that activate the integrative properties and functions of the brain, as well as increase the body’s resistance to aggressive influences. Nootropics, namely piracetam and its analogues, are successfully used in neurological, psychiatric and drug treatment practice. At the same time, the intranasal route of administration is attractive for combined and longterm therapy of these diseases. when developing new intranasal compositions, the issues of choosing the optimal combination of excipients that allow the dosage form to be easily distributed in the nasal cavity must be resolved. The selection of optimal compositions based on consistency properties is possible on the basis of rheological research data, which allows not only to predict the properties of the dosage form being developed, but also to select the required composition and ratio of components. In addition, an important indicator of the quality of soft dosage forms that affects consumer properties is their stability during transportation and storage, as well as such an indicator as spreadability.Aim. Selection of the optimal composition of the gel with piracetam based on rheological characteristics and predicting the thermal and colloidal stability of the gel structure.Materials and methods. Carboxymethyl cellulose, chitosan and carbopol were chosen as the gel base. The rheological characteristics of the samples were studied by rotational viscometry on a Fungilab Premium viscometer (Spain). Data were obtained and collected using Fungilab Data Boss software; additional data processing was carried out using Microsoft Excel.Results. The gelling agent was selected and its rheological characteristics were determined.Conclusion. The optimal composition of excipients piracetam gel was selected taking into account the basic rheological parameters.
