The structural landscape of the immunoglobulin fold by large-scalede novodesign
Jorge Roel-Touris,
Lourdes Carcelén,
Enrique Marcos
Abstract:De novodesigning immunoglobulin-like frameworks that allow for functional loop diversification shows great potential for crafting antibody-like scaffolds with fully customizable structures and functions. In this work, we combinedde novoparametric design with deep-learning methods for protein structure prediction and design to explore the structural landscape of 7-stranded immunoglobulin domains. After screening folding of nearly 4 million designs, we have assembled a structurally diverse library of ∼50,000 imm… Show more
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