The study evaluated the ZBTB40 gene polymorphism and biochemical parameters in women suffering from osteoporosis

Abstract

Osteoporosis weakens bones. Falling or bumping increases the risk of bone fracture. Due to its lack of symptoms, many people are unaware they have it until they fracture. Bone mineral density testing is a safe, fast, and painless approach to detect osteoporosis or its risk. Spine fractures are diagnosed using traditional X-rays, which cannot measure bone mineral density. Specialized procedures are needed to assess bone mineral density. Multiple bone mineral density tests are available, but the most prevalent and recommended is dual-energy X-ray absorptiometry. DXA X-rays can detect small bone loss percentages. The T-score on the bone density evaluation shows how much bone mass differs from a healthy 20-something. The T-score, measured in standard deviations (SD), indicates whether the bone mass is normal, osteopenia, or osteoporosis. This work examines the genetic variation and function of ZBTB40 rs6426794 G/C, rs 7524102 A/G, and rs 34920465 A/G in osteoporosis etiology using molecular methods. The Baghdad Teaching Hospital Bone Density Unit conducts this investigation from September 2020 to January 2021. The DXA test detected osteoporosis in women. Nested PCR was used to investigate the ZBTB40 rs6426794 G/C polymorphism, and biochemic al methods were used to measure vitamin D3 and PTH levels in serum. Calcium concentration was assessed by digestion.