The Study of Dynamic Characteristic of Acupoints Based on the Primary Dysmenorrhea Patients with the Tenderness Reflection on<i>Diji</i>(SP 8)

Chen, Sheng; Miao, Yanhuan; Nan, Yinan; Wang, Yanping; Zhao, Qi; He, Enhui; Sun, Yujing; Zhao, Jiping

doi:10.1155/2015/158012

Cited by 14 publications

(11 citation statements)

References 8 publications

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“…It is worthwhile pointing out that the location and functional status of acupoints are considered dynamic within a certain range of time and space, varying with different physiological and pathological conditions [ 6 – 7 ]. It has also been reported that MCs not only induce a neuro-immuno response by the release of inflammatory mediators following acupuncture; they also play a crucial role in the cross-talk among the circulatory, nervous and immune networks at acupoints [ 8 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine

et al. 2018

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Mast cells (MCs) play a crucial role in mediating the establishment of networks among the circulatory, nervous and immune system at acupoints. However, the changes which occur in MCs during acupoint sensitization, i.e. the dynamic transformation of an acupoint from a "silenced" to an "activated" status, remain uncharacterized. To investigate the morphological and functional changes of MCs as an aid to understanding the cellular mechanism underlying acupoint sensitization, a rat model of knee osteoarthritis (OA) was induced by an injection of mono-iodoacetate (MIA) on day 0. On day 14, toluidine blue and immunofluorescence staining were used to observe the recruitment and degranulation of MCs and the release of mast cell co-expressed mediators: tryptase, 5-hydroxytryptamine (5-HT) and histamine (HA) at the acupoints Yanglingquan (GB34), Heding (EX-LE2) and Weizhong (BL40). Results showed that the number of MCs as well as the percentages of degranulated and extensively degranulated MCs at the acupoints GB34 and EX-LE2 in the light (A), mild (B), heavy (C) osteoarthritis groups were larger than those in the normal control (N) and normal saline (NS) groups (p < 0.01). Comparisons among the A, B and C groups suggested that the number and the degranulation extent of the MCs at the acupoints GB34 and EX-LE2 were positively correlated with the severity of the disease. Some MCs in the A, B and C group showed the release of 5-HT, HA, and tryptase in degranulation at the acupoints GB34 and EX-LE2. Such changes in MCs were not observed at the acupoint BL40. In conclusion, this study confirmed that acupoint sensitization is associated with the increase in recruitment and degranulation levels of MCs on a acupoint-specific and disease severity-dependent manner. The release of tryptase, 5-HT, and HA during MC degranulation is likely to be one of the cellular mechanisms occurring during acupoint sensitization.

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Section: Introductionmentioning

confidence: 99%

Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine

et al. 2018

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“…The pressure pain threshold (PPT) is a semiobjective method used to quantify localised pain 22 23. Clinical studies have confirmed that the sensitivity (PPT) at acupoints changes when patients are in a diseased state, such as shoulder pain,24 knee osteoarthritis,25 primary dysmenorrhea26 and premenstrual syndrome 27. The degree of change in the PPT may objectively reflect the intensity of acupoint sensitisation and it may be related to the disease status 28.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for chronic neck pain with sensitive points: study protocol for a multicentre randomised controlled trial

et al. 2019

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IntroductionChronic neck pain is a challenging condition to treat in clinical practice and has a considerable impact on quality of life and disability. According to the theory of traditional Chinese medicine, acupoints and tender points may become sensitised when the body is in a diseased state. Stimulation of such sensitive points may lead to disease improvement and improved clinical efficacy. This study aims to evaluate the efficacy and safety of needling at sensitive acupoints in providing pain relief, improvement of cervical vertebral function and quality of life in patients with chronic neck pain.Methods and analysisThis multicentre, randomised controlled, explanatory and parallel clinical trial will include 716 patients with chronic neck pain. Study participants will be randomly assigned in a 1:1:1:1 ratio to four treatment groups: the highly sensitive acupoints group, low/non-sensitive acupoints group, sham acupuncture group and waiting-list control group. The primary outcome will be the change in the visual analogue scale score for neck pain from baseline to 4 weeks. Secondary outcomes will be the Northwick Park Neck Pain Questionnaire and McGill pain questionnaire, 12-item Short-Form health survey, Neck Disability Index, changes in the pressure pain threshold, range of cervical motion, Self-Rating Anxiety Scale, Self-Rating Depression Scale and adverse events before treatment, post-treatment, and at 4, 8, 12, 16 and 20 weeks post-treatment. The intention-to-treat approach will be used in the statistical analysis. Group comparisons will be undertaken using χ2tests for categorical characteristics, and analysis of variance for continuous variables to analyse whether acupuncture in the highly sensitive acupoints group achieves better treatment outcomes than in each of the other three groups.Ethics and disseminationEthical approval of this study has been granted by the local Institutional Review Board (ID: 2017 KL-038). The outcomes of the trial will be disseminated through peer-reviewed publications.Trial registration numberChiCTR1800016371; Pre-results.

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“…Some are located in the pathological local areas: in patients with gastric ulcer, pressure-pain threshold (PPT) was found to be decreased significantly on Burong (ST19) and Liangmen (ST21), which are located on the anterior abdomen [29]. It was further reported that pain- and heat-sensitized acupoints were also located in distal areas along the corresponding meridians [30, 35, 40, 41] or bilateral sides of the spine in diseases like allergic rhinitis, lumbar disc herniation, and asthma [38, 39, 42]. Beyond this, some sensitized acupoints have been reported as extra acupoints (they are not on the 14 recognized meridians but have specific names, locations, related diseases, and clinical usage) under certain conditions.…”

Section: Resultsmentioning

confidence: 99%

Understanding Acupoint Sensitization: A Narrative Review on Phenomena, Potential Mechanism, and Clinical Application

Tan

Tumilty

Chapple

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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As part of traditional Chinese medicine, acupoints are considered a dynamic functional area, which can reflect the internal condition of the body. When the body is suffering from disease or injury, corresponding acupoints are believed to be activated and manifest in several sensitized forms, including expansion of the receptive field, pain sensitization, and heat sensitization. Such phenomena are believed to gradually disappear concomitantly with recovery from the disease. Acupoint states are therefore changeable according to health status, a phenomenon known as acupoint sensitization. This review aims to provide an overview of acupoint sensitization based on existing research results and determine priorities for future research. Systematic literature retrieval was conducted in Medline, Embase, Cochrane Library, CINAHL, and AMED from inception to 18 July 2018. Current evidence from research findings to date indicate that acupoint sensitization is based on neurogenic inflammation and that stimulation of sensitized acupoints presents a potential trend of generating a better clinical effect when compared with stimulation of unsensitized points.

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The Study of Dynamic Characteristic of Acupoints Based on the Primary Dysmenorrhea Patients with the Tenderness Reflection onDiji(SP 8)

Cited by 14 publications

References 8 publications

Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine

Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine

Acupuncture for chronic neck pain with sensitive points: study protocol for a multicentre randomised controlled trial

Understanding Acupoint Sensitization: A Narrative Review on Phenomena, Potential Mechanism, and Clinical Application

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