The study of immunological component in antitumor effect of Trypanosoma cruzi

Zenina, A. V.; Кравцов, Э. Г.; Цэцэгсайхан, Батмонх; Yashina, N. V.; Далин, М. В.; Karpenko, L. P.; Sheklakova, L. A.; Kallinikova, V. D.

doi:10.1007/s10517-008-0089-3

Cited by 26 publications

(18 citation statements)

References 5 publications

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“…16 This hypothesis is supported by the observation that Ehrlich's adenocarcinoma growth is significantly impaired in mice injected with splenocytes from animals immunized with T. cruzi lysate. 23 Inhibition of tumor growth by the passively transferred immunocompetent cells suggests that T. cruzi and Ehrlich's adenocarcinoma cells display common epitopes. The authors confirmed the presence of some common surface antigens between T. cruzi and Ehrlich's adenocarcinoma cells.…”

Section: (Conicet) Buenos Aires Argentinamentioning

confidence: 99%

“…It has been proposed that the immune response elicited by T. cruzi could be effective toward tumor cells . This hypothesis is supported by the observation that Ehrlich's adenocarcinoma growth is significantly impaired in mice injected with splenocytes from animals immunized with T. cruzi lysate . Inhibition of tumor growth by the passively transferred immunocompetent cells suggests that T. cruzi and Ehrlich's adenocarcinoma cells display common epitopes.…”

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confidence: 97%

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Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers

Ubillos

Freire

Berriel

et al. 2015

Intl Journal of Cancer

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Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, has anticancer effects mediated, at least in part, by parasitederived products which inhibit growth of tumor cells. We investigated whether immunity to T. cruzi antigens could induce antitumor activity, using two rat models which reproduce human carcinogenesis: colon cancer induced by 1,2-dimethylhydrazine (DMH), and mammary cancer induced by N-nitroso-N-methylurea (NMU). We found that vaccination with T. cruzi epimastigote lysates strongly inhibits tumor development in both animal models. Rats immunized with T. cruzi antigens induce activation of both CD4 1 and CD8 1T cells and splenocytes from these animals showed higher cytotoxic responses against tumors as compared to rats receiving adjuvant alone. Tumor-associated immune responses included increasing number of CD11b/c 1 His48 2 MHC II 1 cells corresponding to macrophages and/or dendritic cells, which exhibited augmented NADPH-oxidase activity. We also found that T. cruzi lysate vaccination developed antibodies specific for colon and mammary rat cancer cells, which were capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in vitro. Anti-T. cruzi antibodies cross-reacted with human colon and breast cancer cell lines and recognized 41/60 (68%) colon cancer and 38/63 (60%) breast cancer samples in a series of 123 human tumors. Our results suggest that T. cruzi antigens can evoke an integrated antitumor response involving both the cellular and humoral components of the immune response and provide novel insights into the understanding of the intricate relationship between parasite infection and tumor growth.

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Section: (Conicet) Buenos Aires Argentinamentioning

confidence: 99%

mentioning

confidence: 97%

Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers

Ubillos

Freire

Berriel

et al. 2015

Intl Journal of Cancer

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show abstract

“…The existence of antibody against T. cruzi in mouse was associated with inhibition of tumor growth in vivo (14). In another study, it was demonstrated that cell-mediated immunity had a role in antitumor activity of T. cruzi (15). In this regard, the presence of common antigens between cancers and certain parasites has been reported (16)(17)(18).…”

Section: Introductionmentioning

confidence: 98%

Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes

et al. 2019

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Toxoplasma gondii (T. gondii) is prevalent intracellular parasite and a cause of worldwide infection in the human population. An inhibitory effect of this parasite on cancer growth has been demonstrated in cell culture and animal models. To determine whether the anticancer activities of T. gondii are associated with host immune response, in the current study the reactivity of anti-T. gondii antiserum with the surface of cancer cell lines was investigated. Anti-T. gondii antibodies were raised in rabbit and the reaction of this antiserum in comparison with other anti-parasite antisera (anti-T. vaginalis, anti-hydatid cyst fluid, anti-protoscolices antigens) with mouse melanoma or breast cancer cells lines was investigated using flow cytometry. Anti-T. gondii antiserum reacted markedly with the surface of mouse melanoma and breast cancer cells, and less so with the normal mouse spleen lymphocytes. Meanwhile, the other anti-parasite antisera did not react strongly with the surface of cancer cells compared with normal mouse spleen lymphocytes. In summary, it has been demonstrated herein that anti-T. gondii antiserum may selectively react with the surface of mouse cancer cells but not with normal mouse spleen lymphocytes. Therefore, further study on anti-Toxoplasma antibodies may be useful for directing the application of selective drug delivery in cancer treatment.

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“…In agreement with the result of the first experiment, Zenina, et al and Zhigunova et al reported that transmission of mice spleen cells immunized with antigens of Trypanosoma cruzi to the recipient mice that had already been challenged with Ehrlich's carcinoma resulted in reduction of tumor size. They also showed cellular immune response generated by T. cruzi antigens may be responsible for this anti-cancer effect [17,18].…”

Section: Discussionmentioning

confidence: 97%

Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor

Darani

Nodeh

Ramazaninia

et al. 2018

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The study of immunological component in antitumor effect of Trypanosoma cruzi

Cited by 26 publications

References 5 publications

Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers

Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers

Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes

Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor

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